Keywords: Aβ; amyloid beta; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; AD; Alzheimer's disease; APP; amyloid precursor protein; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived neurotrophic factor; AFM; ato
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Keywords: Actin dynamics; Rho GTPases; dendritic spines; postsynapse; Abi-1; Abelson interacting protein 1; Abp1; actin binding protein 1; ACTN4; α-actinin-4; ADF; actin-depolymerizing factor; ADHD; attention deficit/hyperactivity disorder; ADNP; activity-dependen
Keywords: AIDA; 1-Aminoindan-1,5-dicarboxylic acid; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; eEF-2; eukaryotic elongation factor-2; ERK-2; extracellular signal-regulated kinase 2; FMRP; fragile X mental retardation protein; mGluRs; metabot
Keywords: Estradiol; Estrogens; Androgen; Neuroactive steroids; MeCP2; FMRP; Trisomy 21; Reelin; Behavior; Animal models
Keywords: ASDs; Autism spectrum disorders; CNV; copy number variant; eIPSC; evoked IPSC; FMRP; fragile X mental retardation protein; FXS; fragile X syndrome; LOH; loss of heterozygosity; LTD; long-term depression; LTP; long-term potentiation; mEPSCs; miniature exci
Keywords: ASD; autism spectrum disorder; DG; dentate gyrus; ELS; early life seizures; EPM; elevated plus maze; FL; flurothyl; FMRP; fragile X mental retardation protein; GH; global hypoxia; HT; hyperthermia; ID; intellectual disability; KA; kainic acid; KO; knock o
Keywords: ASD; autism spectrum disorder; ELS; early-life seizure; FMRP; fragile X mental retardation protein; ID; intellectual disability; KA; kainic acid; KO; knockout; mGluRs; metabotropic glutamate receptors; mLTD; mGluR-mediated long-term depression; P; postnat
Keywords: Fragile X; FMRP; Fmr1; Hippocampus; Dentate gyrus; Synaptic plasticity; LTP; NMDA; Stress
Keywords: AID/APOBEC; activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme complex; BDNF; brain-derived neurotrophic factor; 5caC; 5-carboxylcytosine; CBP; CREB binding protein; CREB; cAMP response binding protein; DNMT; DNA methyltransferases
Keywords: Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: CNS; central nervous system; CreERT2; inducible Cre; CSF; cerebral spinal fluid; EEG; electroencephalography; 4E-BP1; eIF4E-binding protein 1; E; embryonic day; fl; floxed; FCDs; focal cortical dysplasias; FMR1; FMRP gene; FMRP; fragile X mental retardati
Keywords: BAC; Bacterial Artificial Chromosomes; BLBP; brain lipid-binding protein; CLIP; crosslinking-IP; coup-TF; chicken ovalbumin upstream promoter transcription factor; CP; cortical plate; CPNs; callosal projection neurons; CSMNs; corticospinal motor neurons;
Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome
Keywords: BK; Large conductance potassium channel; CA1-PCs; CA1 pyramidal cells; CA3-PCs; CA3 pyramidal cells; DG; Dentate gyrus; EC2; Layer 2 of entorhinal cortex; EC3; Layer 3 of entorhinal cortex; EC5; Layer 5 of entorhinal cortex; Fmr1-KO or KO; Fmr1 knockout;
Dynamic duo - FMRP and TDP-43: Regulating common targets, causing different diseases
Keywords: RNA binding proteins; FMRP; TDP-43; mRNA targets; Fragile X syndrome; Amyotrophic lateral sclerosis; Frontotemporal dementia;
Impaired Neuronal Differentiation of Neural Stem Cells Lacking the Engrailed-2 Gene
Keywords: ANOVA; analysis of variance; ASD; autism spectrum disorders; BDNF; brain-derived neurotrophic factor; d; days in vitro; E; embryonic day; En; engrailed; EthD-1; ethidium homodimer-1; FMRP; Fragile-X mental retardation protein; GABA; γ-aminobutyric acid;
Loss of Sodium-Activated Potassium Channel Slack and FMRP Differentially Affect Social Behavior in Mice
Keywords: ASD; autism spectrum disorder; FMRP; Fragile-X-Mental-Retardation-Protein; FXS; Fragile-X-Syndrome; KO; knockout; MNTB; molecular nucleus of the trapezoid body; Slo2.2; sodium-activated potassium channel Slack; WT; wild type; slack; Slo2.2; FMRP; Fragile-
Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056
Keywords: mGluR5; Fmr1; MRZ-8456; AFQ-056; MPEP; Amyloid-beta precursor protein; Aβ; amyloid-beta; ABC-C; Aberrant Behavior Checklist-Community Edition; AGS; audiogenic-induced seizures; APP; amyloid-beta protein precursor; CNS; central nervous system; CTEP; 2-chl
RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline
Keywords: Germ cell differentiation; RNA binding proteins; LIN28; DAZL; BOLL; FMRP;
A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14
Keywords: CDS; coding sequence; co-IP; co-immunoprecipitation; FBS; fetal bovine serum; FMRP; fragile X mental retardation protein; KO; knockout; PBS; phosphate-buffered saline; PVDF; polyvinylidene difluoride; RBM14; RNA-binding protein 14; RIP; RNA immunoprecipit
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics
Keywords: NMDA; N-methyl-d-aspartate; DISC-1; disrupted in schizophrenia 1; PCP; phencyclidine; GRIK4; glutamate receptor, ionotropic, kainate, type 4; MAOB; monoamine oxidase B; APOA1; apolipoprotein A1; MEK2; dual-specificity mitogen-activated protein kinase kina
Characterization of ultrasonic vocalizations of Fragile X mice
Keywords: FMRP; Syllable; Courtship separation; USV; Speech impairment; Spectral analysis
The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans
Keywords: FXS; Fragile X syndrome; FXPOI; Fragile X-related primary ovarian insufficiency; FXTAS; Fragile X-associated tremor/ataxia syndrome; FMRP; Fragile X mental retardation protein; ncRNAs; Non-coding RNAs; mRNA; Messenger RNA; lncRNAs; Long non-coding RNAs; A
Zfrp8 forms a complex with fragile-X mental retardation protein and regulates its localization and function
Keywords: Zfrp8; FMRP; Trailer Hitch; Translational repression
Hypothalamic-pituitary-adrenal axis function in Fragile X Syndrome and its relationship to behaviour: A systematic review
Keywords: Fragile X Syndrome; FMR1; FMRP; Autism; Hypothalamic-pituitary-adrenal axis; Cortisol; Corticosterone; Glucocorticoid; Systematic review; KO mouse; HPA;
Memory deficits, gait ataxia and neuronal loss in the hippocampus and cerebellum in mice that are heterozygous for Pur-alpha
Keywords: FMRP; FMR protein; FXTAS; Fragile X Tremor Ataxia Syndrome; HAND; HIV-1 associated neurological disease; animals; mice; knockout; brain pathology; PURA; puralpha;
Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi
Keywords: Fragile X syndrome; FMRP; piwi; piRNA; Germlineco-IP, co-immunoprecipitation; dfmr1, Drosophila fragile X mental retardation 1; dFMRP, Drosophila fragile X mental retardation protein; FMR1, fragile X mental retardation 1; FMRP, fragile X mental retardatio
Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome
Keywords: Fragile X syndrome; Barrel cortex; Sensory processing; Hyperexcitation; In vivo electrophysiology; Fmr1 KO; Whisker system; Gap-crossing task; FMRP; Behavior;
Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocytes
Keywords: BSA, bovine serum albumin; E/I, excitatory/inhibitory; FMRP, Fragile X Mental Retardation Protein; FXS, Fragile X syndrome; GAD, glutamate decarboxylase; MAP2, microtubule-associated protein 2astrocyte; neuron; dendrite; arborization; Fragile X; FMRP
Fragile X syndrome: Are signaling lipids the missing culprits?
Keywords: Fragile X syndrome; FMRP; Diacylglycerol kinase; Diacylglycerol; Phosphatidic acid; Lipid signaling;
Human pluripotent stem cell models of Fragile X syndrome
Keywords: Pluripotent stem cells; Human; Fragile X syndrome; Epigenetics; FMRP; FMR1; Autism; Neural development;
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
Keywords: AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ASD; autism spectrum disorder; BrdU; 5-bromo-2â²-deoxyuridine; CA; cornu ammonis; CaMKII; calcium/calmodulin-dependent protein kinase II; CGG; cytosine-guanine-guanine; DG; dentate gy
Control of spine maturation and pruning through proBDNF synthesized and released in dendrites
Keywords: BDNF; brain-derived neurotrophic factor; DIV; day in vitro; FMRP; fragile X mental retardation protein; MHCI; major histocompatibility class I; mEPSPs; miniature excitatory postsynaptic potentials; myr; myristoylation peptide; nls; nuclear localization si
Fragile X mental retardation protein (FMRP) interacting proteins exhibit different expression patterns during development
Keywords: FMRP; FXR1P; FXR2P; CYFIP1; CYFIP2; 82-FIP
Altered expression of δGABAA receptors in health and disease
Keywords: δGABAA receptor; Tonic inhibition; Expression; Plasticity; Behavior; Disease; CA1; Cornu Ammonis subfield 1 of the hippocampus; CNS; central nervous system; Fmr1-KO; transgenic mice lacking the Fmr1 gene; FMRP; fragile X mental retardation protein; GABAA
The potential role of melatonin on sleep deprivation-induced cognitive impairments: Implication of FMRP on cognitive function
Keywords: 4-HNE; 4-hydroxynonenal; 8-oxo-dG; 7,8-dihydro-8-oxo-deoxyguanine; AD; Alzheimer's disease; ANOVA; analysis of variance; ASD; autism spectrum disorders; DCFH2-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethyl sulfoxide; FMRP; fragile X
Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats
Keywords: ABR; auditory brainstem response; CI; confidence interval; CR; Calretinin; Fmr1; Fragile X mental retardation 1 gene; FMRP; Fragile X mental retardation protein; FXS; Fragile X syndrome; GABA; gamma-aminobutyric acid; GAD; glutamic acid decarboxylase; GBC
GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism
Keywords: GABA; Schizophrenia; Bipolar disorder; Cerebellum; FMRP; mGluR5;
Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure
Keywords: AED; antiepileptic drugs; AMPA; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CaMKII; Calcium/calmodulin-dependent kinase II; Dab1; Disabled-1; EPM; elevated plus maze; FMRP; Fragile X mental retardation 1 protein; GluR1; AMPA receptor subunit 1;
Peroxisome proliferator activated receptor gamma (PPARγ) as a therapeutic target for improvement of cognitive performance in Fragile-X
Keywords: AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CNS; central nervous system; ECM; extra cellular matrix; FMR1 gene; Fragile X mental retardation 1 gene; FMRP; Fragile-X mental retardation protein; FXS; Fragile X syndrome; GLUT-3; gl
Topical ReviewMechanism-Based Treatments in Neurodevelopmental Disorders: Fragile X Syndrome
Keywords: fragile X syndrome; autism; FMRP; metobotropic glutamate receptors; GABA agonists; signal transduction; dendritic translation; synaptic plasticity;
Channelopathies and dendritic dysfunction in fragile X syndrome
Keywords: Voltage-gated ion channels; Dendrites; Integration; Fmr1; FMRP
Invited reviewBDNF in fragile X syndrome
Keywords: FMRP; Fmr1 gene; Mental retardation; Autism; Circuit function; Neural progenitors; Differentiation; aNPCs; adult neural progenitor cells; ADHD; attention deficit and/or hyperactive disorder; BDNF; Brain-derived neurotrophic factor; CYFIP1; FMRP-interactin
Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome
Keywords: FMR1; FMRP; Premutation; Fragile X tremor/ataxia syndrome; FXTAS; Glu transporters; EAAT1; EAAT2; mGluR5;
Reduced activity-dependent protein levels in a mouse model of the fragile X premutation
Keywords: Fragile X premutation; CGG KI mouse; Fmrp; Arc; c-Fos; Western blot; Endophenotype;
Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures
Keywords: Early life seizure; Long-term depression; Metabotropic glutamate receptor; CaMKII; Voltage-gated calcium channels; Autism; ACSF; artificial cerebral spinal fluid; APV; amino-5-phosphonopentanoic acid; CaMKII; calcium-calmodulin kinase II; DMSO; dimethyl s
Distribution of fragile X mental retardation protein in the human auditory brainstem
Keywords: AbN; abducens nucleus; cVCN; caudal ventral cochlear nucleus; DCN; dorsal cochlear nucleus; FMR1/Fmr1; fragile X mental retardation 1 gene; Fmr1 KO; Fmr1 knockouts; FMRP; fragile X mental retardation protein; FMRP+; FMRP positive; FN; facial nucleus; FXS;
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Keywords: Brain-derived neurotrophic factor (BDNF); TrkB signaling; Synaptic plasticity; Long-term potentiation (LTP); Protein synthesis; Translation control; Cytoskeletal dynamics; Arc; activity-regulated cytoskeleton-associated protein; AS; Angelman syndrome; AS-
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism
Keywords: Synaptic plasticity; Developmental disorders; Mental retardation; Fragile X; Fmrp; TSC; PTEN; Neuroligin; Homer; SHANK; SAPAP3;
Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome
Keywords: Intellectual disability; Mitochondria; Mitochondrial dysfunction; Oxidative phosphorylation; Neurogenesis; Neuroplasticity; Down syndrome; Rett syndrome; Autism; Fragile X; Oxidative stress; Drug development; Epigallocatechine-3-gallate; ANT; adenine nucl