Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Actin dynamics; Rho GTPases; dendritic spines; postsynapse; Abi-1; Abelson interacting protein 1; Abp1; actin binding protein 1; ACTN4; α-actinin-4; ADF; actin-depolymerizing factor; ADHD; attention deficit/hyperactivity disorder; ADNP; activity-dependen
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Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; AIDA; 1-Aminoindan-1,5-dicarboxylic acid; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; eEF-2; eukaryotic elongation factor-2; ERK-2; extracellular signal-regulated kinase 2; FMRP; fragile X mental retardation protein; mGluRs; metabot
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ASDs; Autism spectrum disorders; CNV; copy number variant; eIPSC; evoked IPSC; FMRP; fragile X mental retardation protein; FXS; fragile X syndrome; LOH; loss of heterozygosity; LTD; long-term depression; LTP; long-term potentiation; mEPSCs; miniature exci
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ASD; autism spectrum disorder; DG; dentate gyrus; ELS; early life seizures; EPM; elevated plus maze; FL; flurothyl; FMRP; fragile X mental retardation protein; GH; global hypoxia; HT; hyperthermia; ID; intellectual disability; KA; kainic acid; KO; knock o
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ASD; autism spectrum disorder; ELS; early-life seizure; FMRP; fragile X mental retardation protein; ID; intellectual disability; KA; kainic acid; KO; knockout; mGluRs; metabotropic glutamate receptors; mLTD; mGluR-mediated long-term depression; P; postnat
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; AID/APOBEC; activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme complex; BDNF; brain-derived neurotrophic factor; 5caC; 5-carboxylcytosine; CBP; CREB binding protein; CREB; cAMP response binding protein; DNMT; DNA methyltransferases
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; BAC; Bacterial Artificial Chromosomes; BLBP; brain lipid-binding protein; CLIP; crosslinking-IP; coup-TF; chicken ovalbumin upstream promoter transcription factor; CP; cortical plate; CPNs; callosal projection neurons; CSMNs; corticospinal motor neurons;
Abnormal Sleep Architecture and Hippocampal Circuit Dysfunction in a Mouse Model of Fragile X Syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; BK; Large conductance potassium channel; CA1-PCs; CA1 pyramidal cells; CA3-PCs; CA3 pyramidal cells; DG; Dentate gyrus; EC2; Layer 2 of entorhinal cortex; EC3; Layer 3 of entorhinal cortex; EC5; Layer 5 of entorhinal cortex; Fmr1-KO or KO; Fmr1 knockout;
Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; mGluR5; Fmr1; MRZ-8456; AFQ-056; MPEP; Amyloid-beta precursor protein; Aβ; amyloid-beta; ABC-C; Aberrant Behavior Checklist-Community Edition; AGS; audiogenic-induced seizures; APP; amyloid-beta protein precursor; CNS; central nervous system; CTEP; 2-chl
Research PaperDecreased surface expression of the δ subunit of the GABAA receptor contributes to reduced tonic inhibition in dentate granule cells in a mouse model of fragile X syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; GABA receptor; Tonic inhibition; Dentate gyrus; Fmr1 gene; Fragile X mental retardation protein; Fragile X syndrome;
A novel role of fragile X mental retardation protein in pre-mRNA alternative splicing through RNA-binding protein 14
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; CDS; coding sequence; co-IP; co-immunoprecipitation; FBS; fetal bovine serum; FMRP; fragile X mental retardation protein; KO; knockout; PBS; phosphate-buffered saline; PVDF; polyvinylidene difluoride; RBM14; RNA-binding protein 14; RIP; RNA immunoprecipit
The metalloproteinase ADAM10: A useful therapeutic target?
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; APL; Acute Promyelocytic Leukemia; ADAM; A Disintegrin And Metalloproteinase; AP2; Adaptor Protein-2; AD; Alzheimer's Disease; Aβ; Amyloid beta; APP; Amyloid Precursor Protein; ACE; Angiotensin Converting Enzyme; APRIL; A Proliferation-Inducing Ligand; B
Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; NMDA; N-methyl-d-aspartate; DISC-1; disrupted in schizophrenia 1; PCP; phencyclidine; GRIK4; glutamate receptor, ionotropic, kainate, type 4; MAOB; monoamine oxidase B; APOA1; apolipoprotein A1; MEK2; dual-specificity mitogen-activated protein kinase kina
The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; FXS; Fragile X syndrome; FXPOI; Fragile X-related primary ovarian insufficiency; FXTAS; Fragile X-associated tremor/ataxia syndrome; FMRP; Fragile X mental retardation protein; ncRNAs; Non-coding RNAs; mRNA; Messenger RNA; lncRNAs; Long non-coding RNAs; A
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; ASD; autism spectrum disorder; BrdU; 5-bromo-2â²-deoxyuridine; CA; cornu ammonis; CaMKII; calcium/calmodulin-dependent protein kinase II; CGG; cytosine-guanine-guanine; DG; dentate gy
Control of spine maturation and pruning through proBDNF synthesized and released in dendrites
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; BDNF; brain-derived neurotrophic factor; DIV; day in vitro; FMRP; fragile X mental retardation protein; MHCI; major histocompatibility class I; mEPSPs; miniature excitatory postsynaptic potentials; myr; myristoylation peptide; nls; nuclear localization si
Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X syndrome; Fragile X mental retardation protein; Ribosome; Translation; RNA; Neuron;
Altered expression of δGABAA receptors in health and disease
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; δGABAA receptor; Tonic inhibition; Expression; Plasticity; Behavior; Disease; CA1; Cornu Ammonis subfield 1 of the hippocampus; CNS; central nervous system; Fmr1-KO; transgenic mice lacking the Fmr1 gene; FMRP; fragile X mental retardation protein; GABAA
Abnormal neuronal morphology and neurochemistry in the auditory brainstem of Fmr1 knockout rats
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ABR; auditory brainstem response; CI; confidence interval; CR; Calretinin; Fmr1; Fragile X mental retardation 1 gene; FMRP; Fragile X mental retardation protein; FXS; Fragile X syndrome; GABA; gamma-aminobutyric acid; GAD; glutamic acid decarboxylase; GBC
Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Early life seizure; Long-term depression; Metabotropic glutamate receptor; CaMKII; Voltage-gated calcium channels; Autism; ACSF; artificial cerebral spinal fluid; APV; amino-5-phosphonopentanoic acid; CaMKII; calcium-calmodulin kinase II; DMSO; dimethyl s
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Brain-derived neurotrophic factor (BDNF); TrkB signaling; Synaptic plasticity; Long-term potentiation (LTP); Protein synthesis; Translation control; Cytoskeletal dynamics; Arc; activity-regulated cytoskeleton-associated protein; AS; Angelman syndrome; AS-
Distribution of fragile X mental retardation protein in the human auditory brainstem
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; AbN; abducens nucleus; cVCN; caudal ventral cochlear nucleus; DCN; dorsal cochlear nucleus; FMR1/Fmr1; fragile X mental retardation 1 gene; Fmr1 KO; Fmr1 knockouts; FMRP; fragile X mental retardation protein; FMRP+; FMRP positive; FN; facial nucleus; FXS;
Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Intellectual disability; Mitochondria; Mitochondrial dysfunction; Oxidative phosphorylation; Neurogenesis; Neuroplasticity; Down syndrome; Rett syndrome; Autism; Fragile X; Oxidative stress; Drug development; Epigallocatechine-3-gallate; ANT; adenine nucl
Development of allosteric modulators of GPCRs for treatment of CNS disorders
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; 5MPEP; 5-methyl-6-(phenylethynyl)-pyridine; 6-OHDA; 6-hydroxydopamine; 7TMR; seven transmembrane receptor; 77-LH-28-1; 1-[3-(4-butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone; AC-42; 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine; ACh
GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; 2iL; 2nd instar larval; AEL; after egg lay; ANOVA; analysis of variance; APL; anterior paired lateral; BSA; bovine serum albumin; ChAT; choline acetyltransferase; CSÂ +; conditioned stimulus; CSÂ â; control stimulus; dBrainbow; Drosophila Brainbow; dfmr
BDNF-induced local protein synthesis and synaptic plasticity
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Brain-derived neurotrophic factor (BDNF); Synaptic plasticity; Long-term potentiation (LTP); Translation; RNA transport; ADF; actin-depolymerizing factor; A2RE; heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element; Arc; activity-regulated c
Short CommunicationMosaicism for FMR1 gene full mutation and intermediate allele in a female foetus: A postzygotic retraction event
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; 5â²UTR; 5â² unstranslated region; Array-CGH; array-Comparative Genomic Hybridization; FMR1; Fragile X Mental Retardation 1 gene; FMRP; Fragile X Mental Retardation Protein; IQ; Intelligence Quotient; PCR; Polymerase Chain Reaction; STR; Short Tandem Rep
Contrast, motion, perceptual integration, and neurocognition in schizophrenia: The role of fragile-X related mechanisms
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ANOVA; analysis of variance; FMRP; fragile X mental retardation protein; FXS; fragile x syndrome; GABA; gamma-aminobutyric acid; HSD; honestly significant difference; M; magnocellular; P; parvocellular; PANSS; Positive and Negative Syndrome Scale; RBANS;
FMRP and myelin protein expression in oligodendrocytes
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X mental retardation protein; Fragile X syndrome; Myelin; Oligodendrocyte; Translation;
ELAV proteins along evolution: Back to the nucleus?
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; RBP; RNA-binding protein; elav; embryonic lethal abnormal vision; miRNA; microRNA; rbp9; RNA-binding protein 9; fne; found in neurons; ARE; AU-rich element; UTR; untranslated region; RRM; RNA recognition motif; PABP; polyA-binding protein; eiF4A; eukaryot
Research ReportAltered auditory processing in a mouse model of fragile X syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; A1; primary auditory cortex; AAF; anterior auditory field; AP; all pass; BP; band pass; CF; characteristic frequency; DSI; direction selectivity index; FM; frequency modulated; FMRP; fragile X mental retardation protein; FP; fast pass; FXS; fragile X synd
Neurobehavioural evidence for the involvement of the FMR1 gene in female carriers of fragile X syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; FXS; fragile X syndrome; PM-carrier; premutation carrier; FX-premutation; fragile X premutation; FMRP; fragile X mental retardation protein; mRNA; messenger RNA; FXS [29]; Premutation [188]; Female [114]; Neurobehavioural [6]; Neuromotor [44]; Executive f
Dendritic protein synthesis in the normal and diseased brain
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; 4E-BPs; eIF4E binding proteins; ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotrophic factor; CaMKII; calcium/calmodulin-dependent kinase II; CPE; cytoplasmic polyadenylation element; CPEB; cytoplasmic polyadenylation element binding protei
Dendritic spine plasticity as an underlying mechanism of neuropathic pain: Commentary on Tan et al.
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; AMPA; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; aPKC; atypical protein kinase C; BDNF; brain derived neurotrophic factor; CCI; chronic constriction injury; DHPG; dihydroxyphenyglycine; FMRP; fragile X mental retardation protein; IL-6; inte
Unusual subcellular confinement of the fragile X mental retardation protein (FMRP) in circulating human platelets: Complete polyribosome dissociation
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X syndrome; Fragile X mental retardation protein; FMRP; Platelets; Cell fractionation; Polyribosomes;
Scaffold protein Homer 1: Implications for neurological diseases
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; EVH1; Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1; IEG; immediate-early gene; P motif; proline-containing motif; mGluR; metabotropic glutamate receptor; IP3R; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potentia
Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; FXS; fragile X syndrome; FMRP; fragile X mental retardation protein; rCPS; regional rate of cerebral protein synthesis; WT; wild type; KO; knock out; Akt; protein kinase B; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3-kinase; ERK; ext
The role of fragile X mental retardation protein in major mental disorders
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X mental retardation protein; Brain; Autism; Schizophrenia; Dendrite; Metabotropic glutamate receptor
Potassium channel modulation and auditory processing
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; FMRP; Fragile X mental retardation protein; AVCN; Anteroventral cochlear nucleus; LSO; Lateral superior olive; MSO; Medial superior olive; MNTB; Medial nuclei of the trapezoid body; Kv; Voltage-gated potassium channel family; PKC; Protein kinase C; CRE; C
RNA granules: The good, the bad and the ugly
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ATXN2; Ataxin-2; BicD; Bicaudal D; CBP; CREB Binding Protein; CPEB; Cytoplasmic Polyadenylation Element Binding protein; DHC; Dynein Heavy Chain; DIC; Dynein Intermediate Chain; FAK; Focal Adhesion Kinase; FUS/TLS/hnRNP P2; Fused in Sarcoma; G3BP; Ras-GAP
MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; MicroRNA; 3′ untranslated region; Brain disorders; Dendrite; Diagnostic marker; Eukaryotic initiation factor; Fragile X mental retardation protein; Human disease; mRNA stability; Plasticity; RNA binding protein; RNA-induced silencing complex; Single nucle
Early developmental alterations in GABAergic protein expression in fragile X knockout mice
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; GABAA; GABAB; Autism; GABA transaminase; Glutamic acid decarboxylase; Developmental expression; Fragile X mental retardation protein
Microtubule-associated Protein 1b, a Neuronal Marker Involved in Odontoblast Differentiation
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X mental retardation protein; human tooth pulp; MAP-1B; MAP2; odontoblasts; tau;
Abnormal Striatal GABA Transmission in the Mouse Model for the Fragile X Syndrome
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; BC1 RNA; electrophysiology; EPSC; fragile X mental retardation protein; mRNA; synaptic plasticity
The fragile X mental retardation protein–RNP granules show an mGluR-dependent localization in the post-synaptic spines
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X mental retardation protein; Spines; Dendritic mRNA; CPEB; Staufen; BC1 RNA; FMR1 mRNA; αCaMKII mRNA
The RNA binding and transport proteins staufen and fragile X mental retardation protein are expressed by rat primary afferent neurons and localize to peripheral and central axons
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; primary afferent neuron; fragile X mental retardation protein; staufen; RNA binding protein; axonal translation; RNA cargo; CPEB; cytoplasmic polyadenylation element binding protein; DRG; dorsal root ganglion; FMRP; fragile X mental retardation protein; I
Fragile X mental retardation protein levels increase following complex environment exposure in rat brain regions undergoing active synaptogenesis
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; Fragile X syndrome; Fragile X mental retardation protein; Synapse; Synaptic plasticity; Dendritic spines; Protein synthesis; Enriched environment; Rat; Brain; Visual cortex; FXR1P; FXR2P;
A null mutation for Fmr1 in female mice: Effects on regional cerebral metabolic rate for glucose and relationship to behavior
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; functional activity; rCMRglc; open field activity; passive avoidance; audiogenic seizures; acoustic startle; CMRglc; global cerebral metabolic rate for glucose; DG; deoxyglucose; FMRP; fragile X mental retardation protein; Fmr1; fragile X mental retardati
Macrocephaly and the control of brain growth in autistic disorders
Keywords: پروتئین عقب ماندگی ذهنی X شکننده است; ACTH; adrenocorticotropin hormone; DNA; deoxyribonucleic acid; EGF; epidermal growth factor; ES; embryonic stem cells; FGF2; fibroblast growth factor 2; FMR-1; fragile X mental retardation 1; FMRP; fragile X mental retardation protein; FoxP2; forkhead box