کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10815805 | 1058505 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RNA granules: The good, the bad and the ugly
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کلمات کلیدی
HDAC6RBPhsfDynein intermediate chainDynein heavy chainTRAF2CPEBHRIPP1DICATXN2Sam68KLCG3BPGCN2tdp43GRB7DHCAggresomeCBPSMNFMRPPrPgrowth factor receptor-bound protein 7RNPFAKSCANMDTNF receptor associated factor 2KHCspinocerebellar ataxia - آتاکسی spinocerebellarspinal muscular atrophy - آتروفی عضلانی نخاعیAtaxin-2 - اتاکسین-2Processing body - بدن پردازشSMA - دبیرستانfused in sarcoma - در سارکوم متصل شده استdynein - دینینKinesin light chain - زنجیره سبک Kinesinkinesin heavy chain - زنجیره سنگین kinesinSurvival of motor neuron - زنده ماندن از نورون موتورHeat shock transcription factor - فاکتور رونویسی شوک حرارتnonsense mediated decay - فساد میانجی گریHeme-regulated inhibitor - مهار کننده هماHistone deacetylase 6 - هیستون دیازتیلاز 6CREB binding protein - پروتئین اتصال CREBcytoplasmic polyadenylation element binding protein - پروتئین اتصال دهنده عنصر polyadenylation سیتوپلاسمیکfragile X mental retardation protein - پروتئین عقب ماندگی ذهنی X شکننده استprotein phosphatase 1 - پروتئین فسفاتاز 1tar DNA-binding protein 43 - پروتئین متصل به DNA DNA 39RNA binding protein - پروتئین متصل به RNAPrion protein - پروتئین پریونPERK - پرکfocal adhesion kinase - کیناز چسبندگی کانونیKinesin - کینزینHAp - گامStress granule - گرانول استرس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: RNA granules: The good, the bad and the ugly RNA granules: The good, the bad and the ugly](/preview/png/10815805.png)
چکیده انگلیسی
Processing bodies (PBs) and Stress Granules (SGs) are the founding members of a new class of RNA granules, known as mRNA silencing foci, as they harbour transcripts circumstantially excluded from the translationally active pool. PBs and SGs are able to release mRNAs thus allowing their translation. PBs are constitutive, but respond to stimuli that affect mRNA translation and decay, whereas SGs are specifically induced upon cellular stress, which triggers a global translational silencing by several pathways, including phosphorylation of the key translation initiation factor eIF2alpha, and tRNA cleavage among others. PBs and SGs with different compositions may coexist in a single cell. These macromolecular aggregates are highly conserved through evolution, from unicellular organisms to vertebrate neurons. Their dynamics is regulated by several signaling pathways, and depends on microfilaments and microtubules, and the cognate molecular motors myosin, dynein, and kinesin. SGs share features with aggresomes and related aggregates of unfolded proteins frequently present in neurodegenerative diseases, and may play a role in the pathology. Virus infections may induce or impair SG formation. Besides being important for mRNA regulation upon stress, SGs modulate the signaling balancing apoptosis and cell survival. Finally, the formation of Nuclear Stress Bodies (nSBs), which share components with SGs, and the assembly of additional cytosolic aggregates containing RNA -the UV granules and the Ire1 foci-, all of them induced by specific cell damage factors, contribute to cell survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Signalling - Volume 23, Issue 2, February 2011, Pages 324-334
Journal: Cellular Signalling - Volume 23, Issue 2, February 2011, Pages 324-334
نویسندگان
MarÃa Gabriela Thomas, Mariela Loschi, MarÃa Andrea Desbats, Graciela Lidia Boccaccio,