Keywords: PI3K; phosphoinositide 3-kinase; MAPK; mitogen activated protein kinase; mTORC1; mTOR complex 1; GCN2; general control nonderepressible 2; ULK; UNC-5 like autophagy activating kinase; ATG; autophagy related gene; GPCR; G protein coupled receptor; UCPs; un
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Keywords: Protein restriction; Aging; Branched-chain amino acids; mTOR; Calorie restriction; GCN2; Protein quality;
Keywords: amino acids; fatty acids; glucose; heart failure; ketone bodies; AA; amino acid; BCAA; branched-chain amino acids; FA; fatty acid; FAO; fatty acid oxidation; GCN2; general control nonderepressible 2; GLOX; glucose oxidation; HBP; hexosamine biosynthesis p
Keywords: SAM; S-adenosylmethionine; Hcy; homocysteine; tHcy; total homocysteine; Bhmt; betaine-Hcy methyltansferase; Mthf; 5-methyltetrahydrofolate-Hcy methyltransferase; Cbs; cystathionine β-synthase; SAH; S-adenosylhomocysteine; DMG; dimethylglycine; HFD; high-
Keywords: Immunometabolism; Nutrient sensing; Glucose; Glutamine; Amino acids; SCFA; LCFA; Cholesterol; Oxysterols; Srebp; mTORC1; c-Myc; GCN2; Slc7a5; CD36; LXR; Glycolysis; OxPhos; Lymphocyte; Macrophage;
Keywords: ATF4; activating transcription factor-4; ATF6α; activating transcription factor-6α; EB1; end binding protein-1; EDEM; ER degradation-enhancing α-like protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; GCN2; general control non-derepre
Keywords: αKG; alpha ketoglutarate; BCAA/LEU; branched chain amino acids enriched with l-leucine; CHOP; C/EBP homology protein; eIF2α; eukaryotic initiation factor 2 alpha; GADD34; growth arrest and DNA damage inducible protein 34; GCN2; general control non-depre
Keywords: GLS; glutaminase; GDH; glutamate dehydrogenase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; TCA; tricarboxylic acid cycle; SS; succinylCoA synthetase; ME; malic enzyme; IDH1; isocytrate dehydrogenase; AARE; aminoacid responsive element
Keywords: amino acids; dietary protein; FGF21; GCN2; leucine; macronutrient
Keywords: Candida albicans; Oxidative stress; Gcn2; Gcn4; Translational regulation
Keywords: 4E-BP1; eIF4E binding protein 1; 5â²-UTR; 5â²-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;
BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562â¯cells
Keywords: BCR-ABL; Integrated stress response; PERK; GCN2; ATF4;
Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells
Keywords: AA; amino acid; AAR; AA response; ATF; activating transcription factor; C/EBP; CAAT/enhancer binding protein; CARE; C/EBP-ATF response element; CRE; cyclic AMP response element; IF2; eukaryotic initiation factor 2; GAPDH; glyceraldehyde 3-phosphate dehydr
Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation
Keywords: GCN; General Control Non-derepresible; GCN1; GCN2; Arabidopsis; Transcriptomic; eIF2α;
Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-κB-GCN2/eIF2α signaling pathway in mammary epithelial cells in vitro and in vivo
Keywords: IFN-γ; Interferon gamma; Arg; Arginine; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; GCN2; general control nonderepressible 2; eIF2α; eukaryotic initiation factor 2; BMECs; bovine mammary epithelial cells; BC; breast cancer; R
Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2
Keywords: Protein synthesis; Translation; Translational control; eIF2; eIF2B; Gcn2; Control engineering; Robustness;
GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice
Keywords: ALT; alanine transaminase; AST; aspartate transaminase; Atgl; adipose triglyceride lipase; AU; arbitrary unit; AUC; area under the curve; BSA; bovine serum albumin; CHOP; C/EBP homologous protein; Cpt2; carnitine palmitoyltransferase 2; DHE; dihydroethidi
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance
Keywords: Endoplasmic reticulum; Epigenetics; Obesity; Triglycerides; Insulin resistance; BMI; body mass index; CASP12; caspase 12; CpG; cytosine-phosphate-guanine site; DBP; diastolic blood pressure; DiOGenes; diet obesity and genes dietary trial; DNAJC1; dnaJ hea
Comparative transcriptome analysis reveals multiple functions for Mhy1p in lipid biosynthesis in the oleaginous yeast Yarrowia lipolytica
Keywords: ACL; ATP-citrate lyase; cAMP; cyclic AMP; CS; citrate synthase; GABA; gamma-aminobutyric acid; GC; gas chromatograph; Gcn2; general control nonderepressible 2; GO; Gene Ontology; IPM; isopropylmalate; KEGG; Kyoto Encyclopedia of Genes and Genomes; LP; lip
Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules
Keywords: SG; stress granule; Tudor-SN; Tudor staphylococcal nuclease; JNK; c-Jun N-terminal kinase; PKR; protein kinase R; PERK; PKR-like endoplasmic reticulum kinase; GCN2; general control nonderepressible 2; HRI; heme-regulated inhibitor kinase; eIF2α; eukaryot
A new role of GCN2 in the nucleolus
Keywords: GCN2; Amino acid starvation; Nucleolus; p53; RNA polymerase III; ARPP P0; acidic ribosomal phosphoprotein P0; ATF4; activating transcription factor 4; BRF1; B-related factor 1; eIF2α; eukaryotic initiation factor 2 alpha subunit; FC; fibrillar center; GA
Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2
Keywords: ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; eIF2α; eukaryotic initiation factor 2 alpha; eIF2α-P; phosphorylated eukaryotic initiation factor 2; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage protein 34; GCN
Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells
Keywords: LGALS3; Galectin 3; LGALS1; Galectin 1; AML; Acute myeloid leukemia; qRT-PCR; Real-time PCR; AKT; Protein kinase B; ERK; Extracellular receptor kinase; BCL2; B cell lymphoma 2; BCL-XL; B cell lymphoma 2 Like 1; MCL-1; Myeloid cell leukemia 1; Ph +;  Phi
Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2α phosphorylation in prostate cancer
Keywords: CHO; Chinese hamster ovary; CHX; cycloheximide; DIG; digoxigenin; FACS; fluorescence-activated cell sorting; GCN2; general control non-derepressible-2; HRI; heme regulated inhibitor of translation; IRES; internal ribosome entry sites; ITAFs; IRES trans-ac
MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells
Keywords: AA; amino acid; AAR; AA response; ActD; actinomycin D; ASNS; asparagine synthetase; ATF4; activating transcription factor 4; cFOS; FBJ murine osteosarcoma viral oncogene homolog; DOX; doxycycline; eIF2; eukaryotic initiation factor 2; ERK; extracellular-s
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2
Keywords: Translational regulation; GCN2; eIF2; GCN1; IMPACT; YIH1;
The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1
Keywords: Apoptosis; Mcl-1; Degradation motif; PEST domain; β-TrCP; β-transducin repeat-containing protein; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma-2; BH domain; Bcl-2 homology domain; Bim; Bcl-2-interacting mediator; BSA; bovine serum albumin; Ca
GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice
Keywords: EAE; GCN2; Foxp3; IDO; pDCs;
Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans
Keywords: C. elegans; Caenorhabditis elegans; WT; wild-type; EF4; elongation factor 4; mtEF4; mitochondrial EF4; mtDNA; mitochondrial DNA; BP; base pairs; ETC; electron transport chain; mtEFTu, mtEFG1 and mtEFTs; mitochondrial elongation factor Tu, G1 and Ts; MMP;
Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation
Keywords: AAR; amino acid response; Apaf-1; apoptotic protease-activating factor-1; ATF; activating transcription factor; Bcl-2; B cell lymphoma-2; Bax; Bcl-2-associated X protein; Bim; Bcl-2-interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein
Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels
Keywords: Heat shock factor 1; Amino acid deprivation; Methionine; DNAJB1; NRF2; GCN2; general non-derepressible 2; ATF; activating transcription factor; ASNS; asparagine synthetase; SAM; S-adenosylmethionine; HMOX1; heme oxygenase 1; GSTP; glutathione S-transferas
Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory
Keywords: Translation initiation; Synaptic plasticity; long-term memory; Knockout eIF2; GCN2; PERK; PKR; HRI;
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; ATF4; activating transcription factor 4; ca; constitutively active; dn; dominant negative; ERK; extracellular signal-related protein kinase; FBS; fetal bovine serum; GCN2; general control non-dere
A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis
Keywords: PKZ; a protein kinase containing Z-DNA binding domains; PKR; protein kinase R; eIF2α; eukaryotic initiation factor 2α; HRI; heme-regulated eIF2α kinase; PERK; RNA-regulated protein kinase (PKR)-like endoplasmic reticulum kinase; GCN2; general control n
Identity crisis of Th17 cells: Many forms, many functions, many questions
Keywords: JAK; janus kinase; STAT; signal transducer activator of transcription; mTOR; mammalian target of rapamycin; GCN2; general controlled non-derepressible 2; Th17 cells; Plasticity; IL-17; RORC; RORγt; CCR6; CD161;
Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2α system
Keywords: GAAC; general amino acid control; HM; hydrophobic motif; PIF; PDK1-interacting fragment; Yeast; Gcn2; PDK1; Pkh1-3; PKA; Sch9; PKB;
Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation
Keywords: Leucine; Myoblast; Differentiation; myf5; myoD; mTOR; GCN2
Endoplasmic reticulum stress enhances γ-secretase activity
Keywords: ER; endoplasmic reticulum; UPR; unfolded protein response; PS; presenilin; ATF4; activating transcription factor 4; GCN2; general control non-derepressible 2; PKR; protein kinase RNA; PERK; PKR-like ER kinase; HRI; heme-regulated inhibitor; eIF2α; eukary
Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo
Keywords: GCN2; Leucine-imbalanced diet; Oxidative stress; GPX1; Hepatic protein carbonylation
Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway
Keywords: GCN2; ATF4; p8; AARE; Amino acid
RNA granules: The good, the bad and the ugly
Keywords: ATXN2; Ataxin-2; BicD; Bicaudal D; CBP; CREB Binding Protein; CPEB; Cytoplasmic Polyadenylation Element Binding protein; DHC; Dynein Heavy Chain; DIC; Dynein Intermediate Chain; FAK; Focal Adhesion Kinase; FUS/TLS/hnRNP P2; Fused in Sarcoma; G3BP; Ras-GAP
CD11c+CD8+ T cells: Two-faced adaptive immune regulators
Keywords: 1-MT, 1-methyl d,l-tryptophan; GCN2, general control non-derepressible-2; IDO, indoleamine 2,3-dioxygenaseCD11c+CD8+ T cells; 4-1BB; IFN-γ; IDO; GCN2
Molecular mechanisms involved in the adaptation to amino acid limitation in mammals
Keywords: Amino acid; Gene expression; GCN2; ATF4; ATF2
Stress Signaling in the Methionine-Choline-Deficient Model of Murine Fatty Liver Disease
Keywords: Steatosis; Steatohepatitis; Endoplasmic Reticulum Stress; Integrated Stress; apoB100; apolipoprotein B100; ATF6; activating transcription factor-6; Bcl-xL; B-cell lymphoma extra-large; BiP; immunoglobulin-binding protein; CHOP; C/EBP homologous protein; e
GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes
Keywords: Oocyte; GCN2; eIF2; Protein synthesis; Translational control
Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2α
Keywords: ATF-4; Activating transcription factor-4; CHOP; C/EBP [CCAAT/enhancer binding protein] homologous protein (also known as GADD153); eIF2α; α-subunit of the eukaryotic translation initiation factor-2; eIF4; Eukaryotic translation initiation factor-4; GAAD
Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes
Keywords: Amino acid; Gene expression; GCN2; Myotube; Myoblast
Altered protein synthesis is a trigger for long-term memory formation
Keywords: Translation; Protein kinase; Learning; PKM-ζ; Positive feedback; Knockout mouse; mTOR; GCN2; eIF2; 4E-BP; S6K
Eukaryotic initiation factor 2α kinase is a nitric oxide-responsive mercury sensor enzyme: Potent inhibition of catalysis by the mercury cation and reversal by nitric oxide
Keywords: HRI; heme-regulated eIF2α kinase or heme-regulated inhibitor; eIF2α; α-subunit of eukaryotic initiation factor 2; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; Fe3+-hemin; Fe3+-protoporphyrin IX complex; Fe2+-heme; Fe2+-proto
Role of amino acids in the translational control of protein synthesis in mammals
Keywords: eEF; eukaryotic elongation factor; eIF; eukaryotic initiation factor; GCN2; general control nonderepressible; His-RS; histidyl-tRNA synthetase; MES; mouse embryonic stem; met-tRNAi; initiator methionyl-tRNA; mTOR; mammalian target of rapamycin; PI 3-kinas