کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1934718 | 1050649 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes](/preview/png/1934718.png)
چکیده انگلیسی
GCN2 is one of the four mammalian kinases that phosphorylate the alpha subunit of the translation initiation factor 2 (eIF2α) in a variety of stress situations, resulting in protein synthesis inhibition. GCN2 is involved in regulating metabolism, feeding behavior and memory in rodents. We show here that, relative to other cells, the beta isoform of the GCN2 transcript and the GCN2 protein are highly abundant in unfertilized mouse eggs. In addition, GCN2 in these cells is active, resulting in elevated levels of phosphorylated eIF2α. After fertilization, eIF2α phosphorylation decreases drastically. These results suggest that GCN2 mediated translational control may contribute to regulatory mechanisms operating during oocyte maturation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 378, Issue 1, 2 January 2009, Pages 41–44
Journal: Biochemical and Biophysical Research Communications - Volume 378, Issue 1, 2 January 2009, Pages 41–44
نویسندگان
Viviane S. Alves, Fabiana L. Motta, Martín Roffé, Arthur Delamano, João B. Pesquero, Beatriz A. Castilho,