کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8450533 | 1547684 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-κB-GCN2/eIF2α signaling pathway in mammary epithelial cells in vitro and in vivo
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کلمات کلیدی
LAMB2CDK9GCN2DAPK3BMECsDUSP10PLD2RalBP1CTNNB1K-Rascasp8Smad3eIF2αIFN-γPrkcaqRT-PCRKRASDVL1NF-κBMothers against decapentaplegic homolog 3Arginine - آرژنین Arg - ارگImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیRelA - رالاquantitative reverse transcription-PCR - رونویسی معکوس PCRBreast cancer - سرطان پستانBovine mammary epithelial cells - سلول های اپیتلیال پستان مولد گاوeukaryotic initiation factor 2 - عامل آغاز کننده یوکاریوتی 2nuclear factor kappa-light-chain-enhancer of activated B cells - فاکتور هسته ای kappa-light-chain-enhancer از سلول های B فعال شده استPhospholipase D2 - فسفولیپاز D2Caspase-8 - کاسپاز-8general control nonderepressible 2 - کنترل کلی غیر قابل تعویض 2Cyclin-dependent kinase 9 - کیناز وابسته به سیکلین 9Interferon gamma - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Breast cancer is the most common female malignant tumors in the world. It seriously affects women's physical and mental health and the leading cause of cancer death among women. Our previous study demonstrated that diet-derived IFN-γ promoted the malignant transformation of primary bovine mammary epithelial cells by accelerating arginine depletion. The current study aimed to explore whether arginine addition could inhibit the degree of malignant transformation and its molecular mechanism. The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-γ, including reducing cell proliferation, cell migration and colony formation, through the NF-κB-GCN2/eIF2α pathway. The in vivo experiments also consistently confirmed that arginine supplementation could significantly inhibit tumor growth in tumor-bearing mice. Furthermore, the investigation of the clinical data also revealed that the plasma or tissue from human breast cancer patients owned lower arginine level and higher IFN-γ level than that from patients with benign breast disease, showing IFN-γ may be a potential control target. Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-γ (nutritionally induced) both in vitro and in vivo, and IFN-γ was higher in breast cancer women. This might provide a novel strategy for the prevention and treatment of breast cancer regarding to nutrition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 368, Issue 2, 15 July 2018, Pages 236-247
Journal: Experimental Cell Research - Volume 368, Issue 2, 15 July 2018, Pages 236-247
نویسندگان
Wenbo Ren, Yang Li, Xiaojing Xia, Wenfei Guo, Taiyu Zhai, Yuting Jin, Yanyi Che, Haidi Gao, Xiumei Duan, Hongxi Ma, Tinghao Huang, Jing Huang, Liancheng Lei,