کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1952672 1538436 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes
چکیده انگلیسی

There is a growing body of evidence that suggests that amino acids play an important role in controlling gene expression, but the cell specificity of the amino-acid-mediated regulation of gene expression in mammals remains unknown. Using a model of muscle cells (C2C12) at two stages of differentiation, i.e. myoblasts and myotubes, we employed transcriptional profiling to show that amino-acid deficiency does not regulate the same set of gene in differentiated and non-differentiated cells. Furthermore, in myotubes, the GCN2 pathway is not activated by amino-acid starvation due to an amino-acid supply from intracellular proteolysis associated with a low GCN2 expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimie - Volume 90, Issues 11–12, November–December 2008, Pages 1716–1721
نویسندگان
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