کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6264615 1614014 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ReportDevelopmental changes in pacemaker currents in mouse locus coeruleus neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research ReportDevelopmental changes in pacemaker currents in mouse locus coeruleus neurons
چکیده انگلیسی

The present study compares the electrophysiological properties and the primary pacemaker currents that flow during the interspike interval in locus coeruleus (LC) neurons from infant (P7-12 days) and young adult (8-12 weeks) mice. The magnitude of the primary pacemaker currents, which consist of an excitatory TTX-sensitive Na+ current and an inhibitory voltage-dependent K+ current, increased in parallel during development. We found no evidence for the involvement of hyperpolarization-activated (IH) or Ca2+ currents in pacemaking in infant or adult LC neurons. The incidence of TTX-resistant spikes, observed during current clamp recordings, was greater in adult neurons. Neurons from adult animals also showed an increase in voltage fluctuations, during the interspike interval, as revealed in the presence of the K+ channel blocker, 4-AP (1 mM). In summary, our results suggest that mouse LC neurons undergo changes in basic electrophysiological properties during development that influence pacemaking and hence spontaneous firing in LC neurons.

► Electrophysiological properties of Locus coeruleus neurons change with development. ► Firing rates are decreased in adult animals. ► Ionic current composition changed with development. ► Voltage-dependent sodium currents increased within the interspike interval. ► Voltage-dependent calcium currents did not change with development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1425, 24 November 2011, Pages 27-36
نویسندگان
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