The effects of sevoflurane anesthesia on rat hippocampus: A genomic expression analysis

► Sevoflurane significantly changes expression of 417 genes in rat hippocampus. ► There is no obvious dose-dependent effect of sevoflurane on gene expression. ► Sevoflurane induced long-term expression change of a large number of genes. ► The expression change of some genes may be related to memory impairment.