Chronic cerebral hypoperfusion in rats causes proteasome dysfunction and aggregation of ubiquitinated proteins

► Chronic cerebral hypoperfusion leads to neurodegeneration. ► Neurodegeneration underlies cognitive dysfunction. ► Chronic cerebral hypoperfusion results in ubiquitinated protein aggregation. ► Ubiquitinated protein aggregation is related to proteasome dysfunction. ► Aberrations in the ubiquitin-proteasome system contributes to neurodegeneration.