Residual effects of focal brain ischaemia upon cannabinoid CB1 receptor density and functionality in female rats

►Middle cerebral artery occlusion (MCAO) was used as a model of ischaemic stroke ►Cannabinoid-1 receptor (CB1R) density was measured by [3H]CP55,940 autoradiography. ►46 days after MCAO, reduced CB1R densities are found in five brain regions ►CB1R functionality was assessed by agonist-stimulated [35S]GTPγS autoradiography ►Reduced CB1R expression is not accompanied by a changed functionality