کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6265579 | 1614147 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Research ReportAge-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Research ReportAge-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease Research ReportAge-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease](/preview/png/6265579.png)
چکیده انگلیسی
A large series of 3-, 6-, 9-, and 12-month-old bigenic mice (NÂ =Â 240) with Swedish APP and A246E PS1 mutations was investigated in nest-building, spontaneous alternation, and two learning tasks. Progressive cognitive impairment was observed in APPswe/PS1 mice relative to controls for nest-building, spontaneous alternation, the reversal phase of left-right discrimination learning in a water-filled T-maze, and in retention of passive avoidance learning. The behavioral deficits in transgenic mice start at 6Â months, appearing to offer an opportunity for assessing potential therapeutic agents in attenuating or preventing Alzheimer's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1292, 25 September 2009, Pages 93-99
Journal: Brain Research - Volume 1292, 25 September 2009, Pages 93-99
نویسندگان
Mohammed Filali, Robert Lalonde,