کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6270764 | 1614742 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of electrolytic lesions of the dorsal diencephalic conduction system on the distribution of Fos-like immunoreactivity induced by rewarding electrical stimulation
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کلمات کلیدی
MPFCFasciculus retroflexusICSSVTABNSTc-fosMFBLHbHSDNACCPUPBSFLIRcaudate-putamen - Caudate-PutamenddC - DDCMedial habenula - habenula پزشکیMHb - MHBstria medullaris - استریا مدولاریFos-like immunoreactivity - ایمونوفیزیک Fos مانندmedial forebrain bundle - بسته نرم افزاری پروبیالanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancehonestly significant difference - تفاوت صادقانه قابل توجه استlateral habenula - حنابا جانبیIntracranial self-stimulation - خود تحریک داخل قلبmedial prefrontal cortex - قشر غده پروسترولPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbensbed nucleus of the stria terminalis - هسته تخت ترمینال های استریlateral hypothalamus - هیپوتالاموس جانبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The dorsal diencephalic conduction system (DDC) is an important pathway of the brain reward circuitry, linking together forebrain and midbrain structures. The present work was aimed at describing the effect of a DDC lesion on the distribution of Fos-like immunoreactivity (FLIR) following intracranial self-stimulation (ICSS) of the lateral hypothalamus (LH). Rats were implanted with monopolar electrodes and divided into three groups; the first two groups were trained to self-stimulate at the LH, whereas the third group received no stimulation and served as a control. Among the two groups that were trained for ICSS, one of them received a lesion at the DDC and was tested for ICSS on the subsequent 5Â days. On the last day of testing, control rats were placed in operant chambers without receiving any stimulation, and the remaining rats were allowed to receive the stimulation for 1Â h. All rats were then processed for FLIR. As previously shown, a lesion at the DDC resulted in significant attenuations of the rewarding effectiveness of LH stimulation. Results also show a higher FLIR in several reward-related areas following LH stimulation, especially in the hemisphere ipsilateral to the stimulation electrode. Compared to non-lesioned rats, lesioned animals had lower FLIR in certain brain regions, suggesting that those regions that were activated by the rewarding stimulation may be functionally interconnected with the DDC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 334, 15 October 2016, Pages 214-225
Journal: Neuroscience - Volume 334, 15 October 2016, Pages 214-225
نویسندگان
Marc Fakhoury, David Voyer, Daniel Lévesque, Pierre-Paul Rompré,