کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6271015 | 1614747 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of maternal hypothyroidism during pregnancy on learning, memory and hippocampal BDNF in rat pups: Beneficial effects of exercise
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کلمات کلیدی
PNDNGFPTUBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Spatial memory - حافظه فضاییgestation day - روز بارداریpostnatal day - روز پس از زایمانbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استnerve growth factor - فاکتور رشد عصبwater maze - ماز آبRat - موش صحراییexercise - ورزشHypothyroidism - کم کاری تیروئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Hypothyroidism during early development leads to numerous morphological, biochemical and functional changes in developing brain. In this study, we investigated the effects of voluntary and treadmill exercise on learning, memory and hippocampal BDNF levels in both hypothyroid male and female rat pups. To induce hypothyroidism in the mothers, 6-propyl-2-thiouracil (PTU) was added to their drinking water (100Â mg/L) from their embryonic day 6 to their postnatal day (PND) 21. For 14Â days, from PNDs 31 to 44, the rat pups were trained with one of the two different exercise protocols, namely the mild treadmill exercise and the voluntary wheel exercise. On PNDs 45-52, a water maze was used for testing their learning and memory ability. The rats were sacrificed one day later and their BDNF levels were then measured in the hippocampus. The findings of the present study indicate that hypothyroidism during the fetal period and the early postnatal period is associated with the impairment of spatial learning and memory and reduced hippocampal BDNF levels in both male and female rat offspring. Both the short-term treadmill exercise and the voluntary wheel exercise performed during the postnatal period reverse the behavioral and neurochemical deficits induced by developmental thyroid hormone insufficiency in both male and female rat offspring. The findings of this study thus demonstrate a marked reversibility of both behavioral and neurochemical disorders induced by developmental thyroid hormone insufficiency through the performance of exercise.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 329, 4 August 2016, Pages 151-161
Journal: Neuroscience - Volume 329, 4 August 2016, Pages 151-161
نویسندگان
Seyed Morteza Shafiee, Abbas Ali Vafaei, Ali Rashidy-Pour,