کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6272952 | 1614792 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential contribution of the hippocampus in two different demanding tasks at early stages of hepatic encephalopathy
ترجمه فارسی عنوان
سهم دیفرانسیل هیپوکامپ در دو وظیفه مختلف خواستار در مراحل اولیه آنسفالوپاتی کبدی
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کلمات کلیدی
PBSPRHCA1c-fos immunoreactivityCA3cornu ammonis 3 - آمون بال 3cornu Ammonis 1 - آمون شاخ 1hepatic encephalopathy - آنسفالوپاتی کبدیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancedentate gyrus - شکنج دندانه دارPortal pressure - فشار پورتالinfralimbic cortex - قشر infralimbicperirhinal cortex - قشر پریحینالprelimbic cortex - قشر پیش از قاعدگیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریreversal learning - معکوس کردن یادگیریRat - موش صحراییcingulate cortex - کورتکس کانگولت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
The hippocampus has been established as a site of plasticity during the acquisition of spatial memory. The memory for spatial locations is impaired in patients who develop hepatic encephalopathy (HE). We wondered how the hippocampus can manage different hippocampal-dependent tasks in a type B model of the early evolutive phases of HE induced by triple portal vein ligation. We used a one-trial object-place recognition task that involves making judgements about whether a stimulus was encountered before in that location and a reversal learning task performed in the Morris water maze that involves reward-guided behavior and decision making. Our behavioral results showed impairments in the acquisition of both tasks by the portal hypertension group compared with the sham-operated group. To label brain areas related to these tasks, we marked the expression of the c-Fos protein and revealed high c-Fos immunoreactivity in cornu ammonis 1 (CA1), cornu ammonis 3 (CA3) and entorhinal (Ent) cortex of the PH group compared with the SHAM group in the object-place recognition task and a decrease in c-Fos-positive cells in the reversal task in the CA1, CA3, dentate gyrus (DG), cingulate (CG), prelimbic (PL), and infralimbic (IL) cortices in the PH group compared with the SHAM group. In conclusion, the study corroborated the pivotal role of the hippocampus in spatial memory deficits found in the early stages of type B HE and noted its differential contribution in each of the tasks.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 284, 22 January 2015, Pages 1-10
Journal: Neuroscience - Volume 284, 22 January 2015, Pages 1-10
نویسندگان
N. Arias, M. Méndez, J.L. Arias,