کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6273141 | 1614791 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
From development to disease: Diverse functions of NMDA-type glutamate receptors in the lower auditory pathway
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کلمات کلیدی
DCNexternal nucleus of the inferior colliculusICXAMPA-RDNLLNMDA-RmGluRMNTBSGNVCNLSOMSOγ-aminobutyric acid - اسید γ-آمینوبوتیریکlong-term depression - افسردگی طولانی مدتIHC - ایمونوهیستوشیمیlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Auditory development - توسعه شنواییlateral superior olive - زیتون برتر جانبیmedial superior olive - زیتون عالیInner hair cell - سلول داخلی داخلیHearing - شنیدن یا شنواییLTD - محدودspiral ganglion neuron - نورون گانگلیون مارپیچیnucleus magnocellularis - هسته magnocellularisventral cochlear nucleus - هسته حلقوی شکمیnucleus laminaris - هسته لامیناریسmedial nucleus of the trapezoid body - هسته مرکزی بدن تراپزیdorsal nucleus of the lateral lemniscus - هسته پشتی لنسیسک جانبیdorsal cochlear nucleus - هسته کچلی پشتیGABA - گاباglutamate - گلوتاماتN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartateN-Methyl-d-aspartate receptors - گیرنده های N-methyl-d-aspartateMetabotropic glutamate receptors - گیرنده های متابوتروپیک گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
N-methyl-d-aspartate receptors (NMDA-Rs) are located at each synapse in the lower auditory pathway of mammals and avians. Characterized by a slow and long-lasting excitatory response upon glutamate activation, their existence in a sensory system biologically engineered for speed and precision seems counterintuitive. In this review we consider the diverse functions of NMDA-Rs. Their developmental regulation and unique subunit composition in the inner ear promote protective and neurotrophic roles following acute insult by regulating AMPA-R expression and assisting in the restoration of synaptic inputs. This contrasts with chronic damage where overactivation of NMDA-Rs is implicated in neuronal death. These functions are thought to be involved in auditory diseases, including noise-induced hearing loss, neural presbycusis, and tinnitus via aberrant excitation. A more traditional role emerges in the developing auditory brainstem, where NMDA-Rs are downregulated and switch subunit composition with maturation. Their biophysical properties also contribute to synaptic dynamics resembling long-term plasticity. At mature synapses they support reliable auditory processing by increasing the probability of action potential generation, regulating first-spike latency, and maintaining reliable action potential firing. Thus, NMDA-R functions in the lower auditory pathway are diverse, contributing to synaptic development, plasticity, temporal processing, and diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 285, 29 January 2015, Pages 248-259
Journal: Neuroscience - Volume 285, 29 January 2015, Pages 248-259
نویسندگان
J.T. Sanchez, S. Ghelani, S. Otto-Meyer,