کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6273339 | 1614796 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological blockage and P2X7 deletion hinder aversive memories: Reversion in an enriched environment
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کلمات کلیدی
BBGBrilliant Blue GP2X7P2X7RLTMMWMrepeated measures - اندازه گیری های مکررanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceFear-conditioning - ترس تهویهlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Fear conditioning - تهدید ترسlong-term memory - حافظه بلندمدتSpatial memory - حافظه فضاییAversive memory - حافظه مخربPurinergic system - سیستم PurinergicMorris water maze - ماز آب آب موریسEnriched environment - محیط غنی شدهknockout - ناکاوتwild-type - نوع وحشیP2X7 receptor - گیرنده P2X7
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Adenosine triphosphate (ATP) plays a role in cell signaling. It was soon proposed that ATP activates ionotropic P2X receptors, exerting an influence on neurons as well as on glial cells. In addition to the fact that the activation of P2X and P2Y receptors can stimulate or inhibit the release of glutamate from rat hippocampal neurons, the release of ATP has been implicated in hippocampal long-term potentiation (LTP). Through different behavioral paradigms, this study aimed to investigate the participation of P2X7R in genetically modified (knockout (KO)) mice with the suppressed expression of this receptor and in the pharmacological blockage of this receptor in rats, as well as to evaluate the effect of environmental enrichment on potential mnemonic deficits. The results suggest that P2X7R participates in aversive memory processes: pharmacological blockage with the selective P2X7R antagonist, A-740003, in different time frames elicited dose-dependent impairments in memory acquisition, consolidation and retrieval in rats that were submitted to the contextual fear-conditioning (FC) task, and the deletion of P2X7R hampered the aversive memory processes of mice that were subjected to the FC paradigm. Experiments using mice that were subjected to environmental enrichment suggest that this form of stimulation reverses mnemonic impairments that are ascribed to the absence of the P2X7R, suggesting that these receptors do not participate on such a reversal. Finally, no alterations were observed in the habituation memory of P2X7KO mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 280, 7 November 2014, Pages 220-230
Journal: Neuroscience - Volume 280, 7 November 2014, Pages 220-230
نویسندگان
R.C. Campos, G.M. Parfitt, C.E. Polese, R. Coutinho-Silva, F.B. Morrone, D.M. Barros,