کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6274692 | 1614828 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Motor stereotypies and cognitive perseveration in non-human primates exposed to early gestational irradiation
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کلمات کلیدی
WGTAVPDOCDCortico-striatalFIM - ENDObsessive compulsive disorder - اختلال وسواس فکریattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیSchizophrenia - اسکیزوفرنی یا شیزوفرنیAutism - اوتیسم یا درخودماندگیcon - باADHD - بیشفعالیneurodevelopment - توسعه عصبیDelayed alternation - جایگزینی تاخیرDopamine - دوپامینBehavior - رفتارRandom sampling - نمونه گیری تصادفیDelayed response - پاسخ تاخیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A number of psychiatric illnesses have been associated with prenatal disturbance of brain development, including autism, attention deficit hyperactivity disorder, and schizophrenia. Individuals afflicted with these disorders exhibit both repetitive motor and cognitive behavior. The potential role that environmental insult to the developing brain may play in generating these aberrant behaviors is unclear. Here we examine the behavioral consequences of an early gestational insult in the non-human primate. Rhesus macaques were exposed to x-irradiation during the first trimester of development to disrupt neurogenesis. The behavior of five fetally irradiated monkeys (FIMs) and five control monkeys (CONs) was observed as they matured from juvenile (1.5Â years) to adult ages (4-5Â years). Home-cage behavior was indistinguishable in the two groups. In the testing cage, circling was prevalent in both groups at juvenile ages, persisting to adulthood in three of the five FIMs. One FIM executed a ritualized motor sequence marked by semi-circling and undulating head movements. Seven macaques (4 FIMs, 3 CONs) were tested on a spatial Delayed Alternation (DA) task as adults. Perseverative errors and non-perseverative errors were recorded in early stages of the testing, at the 0 delay interval. While performing DA, FIMs made more errors of perseveration than CONs yet the number of total errors committed did not differ between groups. The presence of motor stereotypies and cognitive perseveration in fetally irradiated non-human primates suggests that environmental insult to the embryonic brain may contribute to repetitive motor and cognitive behaviors in neuropsychiatric diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 248, 17 September 2013, Pages 213-224
Journal: Neuroscience - Volume 248, 17 September 2013, Pages 213-224
نویسندگان
L.D. Selemon, H.R. Friedman,