[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice

► HNG pretreatment (i.c.v.) decreased TBI-inducted cellular plasmalemma integrality disruption. ► HNG reduced lesion volume even when HNG was administered (i.p.) 2 h post TBI. ► HNG improved the recovery of motor and cognitive dysfunction post TBI. ► HNG pretreatment (i.c.v.) suppresses TBI-induced apoptosis and autophagy.