N-acetylcysteine reverses existing cognitive impairment and increased oxidative stress in glutamate transporter type 3 deficient mice

► EAAT3 knockout mice have hippocampus-dependent and -independent cognitive impairment. ► EAAT3 knockout decreases glutathione levels and increases oxidative stress in many brain regions. ► N-acetylcysteine reverses the existing cognitive and biochemical impairment in EAAT3 knockout mice.