Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons

► We showed that neuroglobin (Ngb) is localized in mitochondria in primary neurons. ► Ngb's mitochondrial localization is increased after OGD. ► Ngb neuroprotection is correlated with increased mitochondrial distribution of Ngb. ► Mitochondria permeability transition pore is involved in Ngb's mito translocation.