Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains

► Central BDNF administration produced ameliorative effect on depressive-like behavior. ► Long-term BDNF effect on “depressive” ASC mice involves profound genetic mechanisms. ► In ASC mice BDNF increased Tph2, Htr1A and Htr2A genes expression. ► In ASC mice BDNF produced sensitization of Htr2A receptor.