The CC chemokine receptor 5 regulates olfactory and social recognition in mice

▶We tested the role of CC chemokine receptor 5 (CCR5) in social behavior and memory. ▶Ccr5−/− mice had better social and olfactory recognition than wild-type (Wt) mice. ▶Administration of CCL3, a ligand for CCR5, impaired social recognition in Wt mice. ▶Spatial and fear conditioning memory were comparable in Wt and Ccr5−/− mice. ▶NMDA-receptor 1 expression was higher in the hippocampi of Ccr5−/− than Wt mice.