Cyclophosphamide-induced disruption of umami taste functions and taste epithelium

▶Chemotherapy drugs disrupt taste functions that complicate cancer treatment. ▶Cyclophosphamide is a DNA alkylating agent that targets normal and cancer cells. ▶Cyclophosphamide disrupted taste acuity and taste thresholds in two phases. ▶Drug-induced toxicity appeared to disrupt taste functions in the first phase. ▶Interruption of taste cell renewal cycle appeared to cause the second phase deficits.