Humanized Foxp2 specifically affects cortico-basal ganglia circuits

▶Humanized Foxp2 enlarges dendritic trees only in the striatum, the thalamus and the neocortex. ▶Humanized Foxp2 increases synaptic plasticity in medium spiny neurons and not in Purkinje cells. ▶Humanized Foxp2 affects only a subset of the traits affected by loss-of-function Foxp2 alleles. ▶Effects of humanized Foxp2 are confined to cortico-basal-ganglia circuits.