کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277193 | 1295749 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge
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کلمات کلیدی
BLAMPFCc-fosDMPFCvmPFCBCIPNBTGADUTPTBSSSCACTHROImRNAmultivariate ANOVAPFCPBSMEA4-nitro blue tetrazolium chloride - 4 تترازولیم کلرید نیترو آبیCeA - CEAglutamic acid decarboxylase - glutamic acid dearboxylaseAmygdala - آمیگدال، بادامهstandard saline citrate - استاندارد سدیم سیتراتinescapable stress - استرس غیر قابل اجتنابAnxiety - اضطرابMANOVA - انتخاب کنیدUridine triphosphate - اوریدین تری فسفاتHelplessness - بی تفاوتیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTris–buffered saline - تریس بافر شورFacilitation - تسهیلاتSensitization - حساسیتdigoxigenin - دیگوکسین ژنmessenger ribonucleic acid - رسوب ریبونوکلئیک اسیدDIG - شماcoefficient of variability - ضریب متغیرmedial prefrontal cortex - قشر غده پروسترولdorsomedial prefrontal cortex - قشر پیش از افسردگی پس از زایمانPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریHPA-axis - محور HPAhypothalamic–pituitary–adrenal axis - محور هیپوتالاموس-هیپوفیز-آدرنالregion of interest - منطقه مورد نظرcentral nucleus of the amygdala - هسته مرکزی آمیگدالadrenocorticotropic hormone - هورمون adrenocorticotropicventromedial prefrontal cortex - کورتکس prefrontal ventromedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge](/preview/png/6277193.png)
چکیده انگلیسی
Control over an aversive experience can greatly impact the organism's response to subsequent stressors. We compared the effects of escapable (ES) and yoked inescapable (IS) electric tail shocks on the hypothalamic-pituitary-adrenal (HPA) axis hormonal (corticosterone and adrenocorticotropic hormone (ACTH)), neural (c-fos mRNA) and behavioral (struggling) response to subsequent restraint. We found that although the HPA axis response during restraint of both previously stressed groups were higher than stress-naïve rats and not different from each other, lack of control over the tailshock experience led to an increase in restraint-induced struggling behavior of the IS rats compared to both stress-naïve and ES rats. Additionally, c-fos expression in the basolateral amygdala was increased selectively in the IS group, and relative c-fos mRNA expression in the basolateral amygdala positively correlated with struggling behavior. Restraint-induced c-fos expression in the medial prefrontal cortex, a brain area critical for mediating some of the differential neurochemical and behavioral effects of ES and IS, was surprisingly similar in both ES and IS groups, lower than that of stress-naïve rats, and did not correlate with struggling behavior. Our findings indicate that basolateral amygdala activity may be connected with the differential effects of ES and IS on subsequent behavioral responses to restraint, without contributing to the concurrent HPA axis hormone response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 138-148
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 138-148
نویسندگان
M.S. Weinberg, N. Grissom, E. Paul, S. Bhatnagar, S.F. Maier, R.L. Spencer,