Keywords: ABC; ATP Binding Cassette; AE; anion exchanger; ASL; airways surface liquid; ATP; adenosine triphosphate; CAP; channel activating protease; CaCC; calcium activated chloride channel; CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane conductance regu
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Keywords: Ala; alanine; Arg; arginine; Asn; asparagine; Asp; aspartic acid; Cys; cysteine; Gln; glutamine; Glu; glutamic acid; Gly; glycine; His; histidine; Ile; isoleucine; Leu; leucine; Lys; lysine; Met; methionine; Phe; phenylalanine; Pro; proline; Ser; serine;
Keywords: AMP; adenosine 5â²-monophosphate; ADP; adenosine 5â²-diphosphate; ATP; adenosine 5â²-triphosphate; CMP; cytidine 5â²-monophosphate; CDP; cytidine 5â²-diphosphate; CTP; cytidine 5â²-triphosphate; dCMP; 2â²-deoxycytidine 5â²-monophosphate; dCTP; 2â
Keywords: AChE; Acetylcholinesterase; AChR; Acetylcholine Receptor; ALG13,14; UDP-N-acetylglucosaminyltransferase subunit 13, 14; AMDHD2; Amidohydrolase domain containing 2; ATP; Adenosine triphosphate; Aβ; Amyloid β; CDG; Congenital disorders of glycosylation; C
Keywords: α-GST; alpha-glutathione S-transferase; B2M; beta-2 microglobulin; BUN; blood urea nitrogen; CROs; contract research organisations; Cr; creatinine; CysC; cystatin C; DIKI; drug-induced kidney-injury; EFPIA; European Federation of Pharmaceutical Industrie
Keywords: Uridine; UTP; UDP; Pyrimidinergic; Neurotransmission; P2Y receptors;
Keywords: Pyrimidine metabolism; Pathogens; CAD; Dihydroorotase; Dihydroorotate dehydrogenase; UMP synthase; CAD; multifunctional protein that initiates and regulates de novo pyrimidine biosynthesis; DHODase; dihydroorotate dehydrogenase; hpi; hours post infection;
Keywords: Pyrimidine biosynthesis; Orotidine monophosphate decarboxylase; Ligand-enzyme interactions; Antimalarial agents; BMP; barbituric acid ribosyl 5â²-monophosphate (6-hydroxy UMP); CTP; cytidine 5â²-triphosphate; dCTP; deoxycytidine 5â²-triphosphate; HMOA;
Keywords: Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator protein; CFTR2; Correctors; Potentiators; Trial end-points; Amil; Amiloride; AMP; Accelerating Medicine Partnership; ANO; anoctamins; AONs; antisense oligonucleotides; ASL; airway surfac
Keywords: NGAL; neutrophil gelatinase-associated lipocalin; NAG; N-acetyl-β-D-glucosaminidase; AKI; acute kidney injury; ROC; receiver operator characteristics; BUN; blood urea nitrogen; Cr; creatinine; uTP; urinary total protein; ELISA; enzyme-linked immunosorben
Keywords: ATP; adenosine-5â²-triphosphate; ADP; adenosine-5â²-diphosphate; AMP; adenosine-5â²-monophosphate; UTP; uridine-5â²-triphosphate; UDP; uridine-5â²-diphosphate; UMP; uridine-5â²-monophosphate; GTP; guanosine-5â²-triphosphate; GDP; guanosine-5â²-dip
Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa
Keywords: X-ray crystallography; Nucleotidyl cyclase toxins; T3SS; Anthrax toxA family; Non-canonical secondary messengers; One-metal-ion dependent catalysis; ExoY; exogenous toxin Y; T3SS; Type III secretory systems; AA-NC; actin-activated nucleotidyl cyclase; EF;
Preliminary analysis of the effect of Stevia (Stevia rebaudiana) in patients with chronic kidney disease (stage I to stage III)
Keywords: Stevia; Chronic kidney disease (CKD); Hypertension; Diabetes mellitus; Angiotensin-II receptor blocker (ARB); Ca2+ channel blocker (CCB); CKD; Chronic Kidney Disease; ARB; Angiotensin-II Receptor Blocker; CCB; Ca2+ Channel Blocker; STV; Stevia; PLC; Place
ZH-1 enhances the anticancer activity of gemcitabine via deoxyribonucleotide synthesis and apoptotic pathway against A549 cells
Keywords: Gemcitabine; ZH-1; Apoptosis; Deoxyribonucleotides; Intrinsic apoptotic pathway; ATCC; American Type Culture Collection; ATP; adenosine-triphosphate; ATP13C15N; trioctylamine, 1,1,2-trichlorotrifluoroethane, stable isotope labeled adenosine-13C1015N5-trip
Establishment of a five-enzyme cell-free cascade for the synthesis of uridine diphosphate N-acetylglucosamine
Keywords: ADP; adenosine diphosphate; ATP; adenosine triphosphate; BWM; bio wet mass; CMP-sialic; cytidine-5â²-monophospho-N-acetylneuraminic acid; FCC; flux control coefficient; GalU; bifunctional Glc-1P uridyltransferase; GDP; guanosine diphosphate; GlcNAc; N-
Fabrication and Use of Poly(d,l-lactide-co-glycolide)-Based Formulations Designed for Modified Release of 5-Fluorouracil
Keywords: 5-FU; 5-fluorouracil; poly(lactic/glycolic) acid (PLGA, PLA); controlled/sustained release/delivery; microparticles; nanoparticles; 5-FU; 5-fluorouracil; dUMP; deoxyuridine monophosphate; DCM; dichloromethane; EPR; enhanced permeation and retention; FdUMP
Tools and drugs for uracil nucleotide-activated P2Y receptors
Keywords: ADP; Adenosine 5â²-diphosphate; AP4A; P1,P4-Di(adenosine-5â²)-tetraphosphate; AR; Adenosine receptor; AR-C118925; 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarbo
Visual and light scattering spectrometric method for the detection of melamine using uracil 5â²-triphosphate sodium modified gold nanoparticles
Keywords: Melamine; Gold nanoparticles; UTP; Hydrogen-bonding;
Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Keywords: ADP; adenosine 5â²-diphosphate; AgRP; agouti-related peptide; AMPK; 5â²-AMP-activated protein kinase; ApnA; diadenosine polyphosphate; ApoE; apolipoprotein E; AT1R; angiotensin II type 1 receptor; ATP; adenosine 5â²-triphosphate; BN-PAGE; blue native-p
CTP synthase forms the cytoophidium in human hepatocellular carcinoma
Keywords: CTPS; cytidine triphosphate synthase; UTP; uridine triphosphate; ATP; adenine triphosphate; DON; 6-diazo-5-oxo-L-norleucine; DAU; deazauridine; HCC; hepatocellular carcinoma; HSP90; heatshock protein 90; MSOX; L-methionine sulfoximine; HIF1α; hypoxia-ind
Pyrrole N-H anion complexes
Keywords: ADP; adenosine diphosphate; AMP; adenosine monophosphate; ATP; adenosine triphosphate; CMP; cytidine monophosphate; CTP; cytidine triphosphate; GMP; guanosine monophosphate; GTP; guanosine triphosphate; PAMAM; polyamido amine dendrimer; PPi; pyrophosphate
Pannexin1 as mediator of inflammation and cell death
Keywords: ASC; apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain; ATP; adenosine-5â²-triphosphate; [Ca2Â +]i; intracellular calcium concentration; CARD; caspase activation and recruitment domain; CT; carboxyterminal; Cx; co
New insights on pyrimidine signalling within the arterial vasculature - Different roles for P2Y2 and P2Y6 receptors in large and small coronary arteries of the mouse
Keywords: Coronary circulation; Knock-out mice; Purinergic receptors; P2Y2; P2Y6; ATP; adenosine triphosphate; ATPγS; adenosine-5â²-O-(3-thiotriphosphate); EC50; 50% of the maximum response; ENTPDase; ectonucleoside triphosphate diphosphohydrolase; ET-1; endothel
Development of a Bacillus subtilis cell-free transcription-translation system for prototyping regulatory elements
Keywords: ATP; adenosine triphosphate; CTP; cytidine triphosphate; GTP; guanosine triphosphate; UTP; uridine triphosphate; GFPmut3b; green fluorescent protein mut3b variant; Mg; magnesium; K; potassium; tRNA; transfer ribonucleic acid; 3-PGA; 3-phosphoglycerate; NA
Indole-3-acetic acid UDP-glucosyltransferase from immature seeds of pea is involved in modification of glycoproteins
Keywords: 2OxIAA; 2-oxindole-3-acetic acid; 2,4-d; 2,4-dichlorophenoxyacetic acid; 4-Cl-IAA; 4-chloro-indole-3-acetic acid; 5-OH-IAA; 5-hydroxy-indole-3-acetic acid; ABA; abscisic acid; BA; benzoic acid; GA3; gibberellic acid; GH3; Gretchen Hagen 3; GTase; glucosyl
Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts
Keywords: [Ca2+]i; intracellular calcium; ADPRC; ADP-ribosylcyclase; ATP; adenosine 5â²-triphosphate sodium salt; ATPγS; adenosine 5â²-[γ-thio]triphosphate tetralithium salt; 2-APB; 2-aminoethoxydiphenylborane; BSA; bovine serum albumin; cADPR; cyclic adenosine
Enhancement of antibody production against rabies virus by uridine 5′-triphosphate in mice
Keywords: UTP; Vaccine; Rabies; Antibody; P2Y4 receptor
Pulmonary, Renal and Hepatic PharmacologyATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors
Keywords: ABC; ATP-binding cassette transporters; Cx43; connexin 43; E-NTPDases; ecto-nucleoside triphosphate diphosphohydrolases; LDH; lactate dehydrogenase; mRNA; messenger ribonucleic acid; Panx1; pannexin-1; TTX; tetrodotoxin; UDP; uridine diphosphate; UTP; uri
P2Y2R activation by nucleotides released from oxLDL-treated endothelial cells (ECs) mediates the interaction between ECs and immune cells through RAGE expression and reactive oxygen species production
Keywords: ATP; adenosine triphosphate; CTRL; control; DAPI; 4',6-diamidino-2-phenylindole dihydrochloride; DMEM; Dulbecco's modified Eagle's medium; DPI; diphenyleneiodonium; EC; endothelial cell; ECL; enhanced chemiluminescence; FBS; fetal bovine serum; H2DCF-
ATP and UTP stimulate bone morphogenetic protein-2,-4 and -5 gene expression and mineralization by rat primary osteoblasts involving PI3K/AKT pathway
Keywords: ATP; adenosine-5â²-triphosphate; ATPγS; adenosine-5â²-O-(thiotriphosphate); ADP; adenosine-5â²-diphosphate); ADPβS; adenosine-5â²-O-(2-thiodiphosphate); BMPs; bone morphogenetic proteins; UTP; uridine-5â²-triphosphate; ALP; alkaline phosphatase; PI
Nucleoside triphosphates inhibit ADP, collagen, and epinephrine-induced platelet aggregation: Role of P2Y1 and P2Y12 receptors
Keywords: ATP; adenosine 5' triphosphate; ADP; adenosine 5' diphosphate; UTP; uridine 5' triphosphate; GTP; guanosine 5' triphosphate; CTP; cytosine 5' triphosphate; α,β,m ATP; α,β-methylene ATP; 2MeSATP; 2-(Methylthio)adenosine 5â²-triphosphate; 2Me
Stability and sustainability: Efficacy of ATP (adenosine triphosphate) relative to GTP, CTP and UTP substantiated by principle of least variance
Keywords: Reactive molecule; ATP; GTP; CTP; UTP; Cell
The activation of P2Y6 receptor in cultured spinal microglia induces the production of CCL2 through the MAP kinases-NF-κB pathway
Keywords: Spinal microglia; CCL2; P2Y6; UTP; MAP kinases; NF-κB
Cellular localization of P2Y6 receptor in rat retina
Keywords: AC; amacrine cell; ATP; adenosine triphosphate; BC; bipolar cell; CB; calbindin D-28k; ChAT; choline acetyltransferase; Chx10; homeobox protein Chx10; CRALBP; cellular retinaldehyde binding protein; DT-PBS; 3% normal donkey serum, 0.2% Triton X-100 and 0.
ATP excites mouse vomeronasal sensory neurons through activation of P2X receptors
Keywords: AC; adenylyl cyclase; ADP; adenosine 5â²-disphosphate; ANOVA; analysis of variance; ATP; adenosine 5â²-triphosphate; BK; big-conductance calcium-activated potassium channel; cAMP; cyclic adenosine 5â²-monophosphate; CACC; calcium-activated chloride cha
The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: The role of p2x receptors
Keywords: ATP; adenosine triphosphate; ADP; adenosine diphosphate; α,β-meATP; α,β-methylene adenosine 5â²-triphosphate; β,γ-meATP; β,γ-methylene adenosine 5â²-triphosphate; Bz-ATP; 2â²(3â²)-O-(4-benzoylbenzoyl) adenosine 5â²-triphosphate; UTP; uridine
UTP reduces infarct size and improves mice heart function after myocardial infarct via P2Y2 receptor
Keywords: Cardioprotection; Ischemia; Knockout mice; P2Y2 receptor; UTP;
Regulation of sodium transport in the inner ear
Keywords: ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; EIPA; ethylisopropylamiloride; EMNE; extramacular non-sensory epithelium; ENaC; epithelial sodium channel; LAASC; low-amiloride-affinity Na+ channel; Nedd; neural precursor cell-expressed
P2Y2 receptor-mediated modulation of estrogen-induced proliferation of breast cancer cells
Keywords: Estrogen; Estrogen receptors; P2Y2 receptor; UTP; Breast cancer
Nuclear β-adrenergic receptors modulate gene expression in adult rat heart
Keywords: AC; adenylyl cyclase; ATP; adenosine triphosphate; βAR; β-adrenergic receptor; CAMKII; Ca2+/calmodulin-dependent protein kinase II; DNA; deoxyribonucleic acid; DTT; dithiothreitol; ET-1; endothelin 1; ERK; extracellular signal-regulated kinase; GPCR; G
Research ReportMg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels
Keywords: oxATP; oxidized ATP; TNFα; tumor necrosis factor-alpha; BzATP; 2â²,3â²-[benzoyl-4-benzoyl]-ATP; UTP; uridine 5â²-triphosphate; KN-62; 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-l-tyrosyl]-4-phenylpiperazine]; MRS2179; N6-methyl-2'-deoxyadenosine-3',5
Copper inhibits P2Y2-dependent Ca2+ signaling through the effects on thapsigargin-sensitive Ca2+ stores in HTC hepatoma cells
Keywords: P2Y2 receptors; UTP; Thapsigargin; Intracellular Ca2+; Cell volume; Copper
Negative regulation of Ca2+ influx during P2Y2 purinergic receptor activation is mediated by Gβγ-subunits
Keywords: GPCR; heptahelical G protein-coupled receptor; βARK; β-adrenergic receptor kinase; Gα; α-subunit of G protein; Gβγ; βγ-subunits of the G protein; Ad-MX17; adenovirus that contains only virus backbone; Ad-EF1-wtGαq; adenovirus expressing α-subuni
Inescapable but not escapable stress leads to increased struggling behavior and basolateral amygdala c-fos gene expression in response to subsequent novel stress challenge
Keywords: facilitation; PFC; amygdala; helplessness; anxiety; sensitization; ACTH; adrenocorticotropic hormone; ANOVA; analysis of variance; BCIP; 5-bromo-4-chloro-3-indoyl-phosphate, 4-toluidine salt; BLA; basolateral/lateral amygdala; CeA; central nucleus of the
The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter
Keywords: AP; Alkaline Phosphatase; BAL1; B-aggressive lymphoma 1; BBAP; B-aggressive lymphoma and BAL1 binding partner; bp; base pair(s); BCIP; 5-Bromo-4-chloro-3-indolyl phosphate toluidine salt; BT; Basal Telencephalon; C; Cytidine; cDNA; complementary DNA; CEI;
Excitation-contraction coupling in resistance mesenteric arteries: Evidence for NKCC1-mediated pathway
Keywords: Mesenteric arteries; K+-induced depolarization; Phenylephrine; UTP; Myogenic tone; Na+, K+, 2Clâ cotransport;
Uridine 5′-triphosphate (UTP) protects against cerebral ischemia reperfusion injury in rats
Keywords: UTP; Cerebral ischemia reperfusion; Rats
Zinc and cortical plasticity
Keywords: 5-HT; 5-hydroxytryptamine; ADP; adenosine diphosphate; AD; Alzheimer's disease; AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; ATP; adenosine triphosphate; BDNF; brain derived neurotrophic factor; Ca-EDTA; calcium ethylenediaminetetraacetic
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists
Keywords: Uracil nucleotide; G protein-coupled receptor; Phospholipase C; UDP; UTP; Dinucleotide; Structure–activity relationships
Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP
Keywords: P2Y2; UTP; Enhanced stability