کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277565 | 1295765 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Variations in catechol-O-methyltransferase gene interact with parenting to influence attention in early development
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کلمات کلیدی
Dopamine D4 receptor geneHPSLPSDRD4Catechol-O-methyltransferaseANCOVACOMTAPs - AP هاanalyses of covariance - تحلیل کوواریانسExecutive attention - توجه اجباریSelf-regulation - خودتنظیمیreaction time - زمان واکنشval - ساعتHaplotype - هاپلوتیپSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدGenotype - ژنوتیپ
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Attention influences many aspects of cognitive development. Variations in the catechol-O-methyltransferase (COMT) gene, known to affect dopamine neurotransmission, have frequently been found to influence attention in adults and older children. In this paper we examined 2 year old children and found that variation in the COMT gene influenced attention in a task involving looking to a sequence of visual stimuli. Because the influence of another dopamine-related gene (DRD4) has been shown to interact with parenting quality at this age, we explored parenting in relation to variations in the COMT gene. Variations in COMT interacted with parenting quality to influence our attention measure. The Val108/158Met polymorphism of COMT is commonly used to determine allelic groups, but recently haplotypes of several polymorphisms within this gene have been shown to be more strongly associated with perceived pain. Since attention and pain both involve the activation of the anterior cingulate gyrus in imaging studies, we compared the Val108/158Met influence with the COMT haplotypes and found the latter to be more predictive of attention. Our results confirm that important aspects of cognitive development including attention depend on the interaction of genes and early environment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 164, Issue 1, 24 November 2009, Pages 121-130
Journal: Neuroscience - Volume 164, Issue 1, 24 November 2009, Pages 121-130
نویسندگان
P. Voelker, B.E. Sheese, M.K. Rothbart, M.I. Posner,