کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277746 | 1295775 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracranial self-stimulation enhances neurogenesis in hippocampus of adult mice and rats
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کلمات کلیدی
MFBGFAPICSSNACSSCTBSPTZVTA5-bromodeoxyuridineNeuNGCLphosphate buffer - بافر فسفاتBrdU - بروموداکسی اوریدینmedial forebrain bundle - بسته نرم افزاری پروبیالanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTris-buffered saline - تریس بافر شورIntracranial self-stimulation - خود تحریک داخل قلبRoom temperature - دمای اتاقprogenitor cells - سلول های پیش گیاهSham - شامdentate gyrus - شکنج دندانه دارgranule cell layer - لایه سلول گرانولblocking buffer - مسدود کردن بافرventral tegmental area - ناحیه تگمنتوم شکمیNeurogenesis - نوروژنزNucleus accumbens - هسته accumbensneuronal nuclei - هسته های نورونیReward - پاداشGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Running is known to promote neurogenesis. Besides being exercise, it results in a reward, and both of these factors might contribute to running-induced neurogenesis. However, little attention has been paid to how reward and exercise relate to neurogenesis. The present study is an attempt to determine whether a reward, in the form of intracranial self-stimulation (ICSS), influences neurogenesis in the hippocampus of adult rodents. We used bromodeoxyuridine labeling to quantify newly generated cells in mice and rats that experienced ICSS for 1 h per day for 3 days. ICSS increased the number of 5-bromodeoxyuridine (Brdu)-labeled cells in the hippocampal dentate gyrus (DG) of both species. The effect, when examined at 1 day, 1 week, and 4 weeks post-ICSS, was predominantly present in the side ipsilateral to the stimulation, although it was distributed to the contralateral side. We also found in rats that, 4 weeks after Brdu injection, surviving newborn cells in the hippocampal DG of the ICSS animals co-localized with a mature neuron marker, neuronal nuclei (NeuN), and these surviving cells in rats were double-labeled with Fos, a marker of neuronal activation, after the rats had been trained to perform a spatial task. The results demonstrate that ICSS can increase newborn neurons in the hippocampal DG that endure into maturity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 402-411
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 402-411
نویسندگان
T. Takahashi, Y. Zhu, T. Hata, C. Shimizu-Okabe, K. Suzuki, D. Nakahara,