کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277885 | 1295777 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective effects of neonatal handling on rat brain N-methyl-d-aspartate receptors
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کلمات کلیدی
MEACA1PNDBLAprelimbicinfralimbicNMDAN-methyl-d-aspartateCA3CeA - CEAIn situ hybridization - Hybridization در محلBrain plasticity - انعطاف پذیری مغزPir - بیش از حدanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceEarly handling - دست زدن به زود هنگامRoom temperature - دمای اتاقpost-natal day - روز بعد از تولدdentate gyrus - شکنج دندانه دارpiriform cortex - قشر پریکومanterior cingulate - مقطع قدامی قدامیHPA - میلی بار یا هکتوپاسکالbasolateral amygdaloid nucleus - هسته آمیگدولئید basolateralcentral amygdaloid nucleus - هسته مرکزی amygdaloidmedial amygdaloid nucleus - هسته مرکزی آمیگدولیدhypothalamic–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالNMDA receptor subunits - واحدهای گیرنده NMDA
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selective effects of neonatal handling on rat brain N-methyl-d-aspartate receptors Selective effects of neonatal handling on rat brain N-methyl-d-aspartate receptors](/preview/png/6277885.png)
چکیده انگلیسی
Neonatal handling, an experimental model of early life experiences, is known to affect the hypothalamic-pituitary-adrenal axis function thus increasing adaptability, coping with stress, cognitive abilities and in general brain plasticity-related processes. A molecule that plays a most critical role in such processes is the N-methyl-d-aspartate (NMDA) receptor, a tetramer consisting of two obligatory, channel forming NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B. Since the subunit composition of the NMDA receptor affects brain plasticity, in the present study we investigated the effect of neonatal handling on NR1, NR2A and NR2B mRNA levels using in situ hybridization, and on NR2B binding sites, using autoradiography of in vitro binding of [3H]-ifenprodil, in adult rat limbic brain areas. We found that neonatal handling specifically increased NR2B mRNA and binding sites, while it had no effect on the NR1 and NR2A subunits. More specifically, neonatally handled animals, both males and females, had higher NR2B mRNA and binding sites in the dorsal CA1 hippocampal area, as well as the prelimbic, the anterior cingulate and the somatosensory cortex, compared to the non-handled. Moreover NR2B binding sites were increased in the dorsal CA3 area of handled animals of both sexes. Furthermore, neonatal handling had a sexually dimorphic effect, increasing NR2B mRNA and binding sites in the central and medial amygdaloid nuclei only of the females. The neonatal handling-induced increase in the NR2B subunit of the NMDA receptor could underlie the higher brain plasticity, which neonatally handled animals exhibit.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 164, Issue 4, 29 December 2009, Pages 1457-1467
Journal: Neuroscience - Volume 164, Issue 4, 29 December 2009, Pages 1457-1467
نویسندگان
A. Stamatakis, E. Toutountzi, K. Fragioudaki, E.D. Kouvelas, F. Stylianopoulou, A. Mitsacos,