کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278246 | 1295802 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of dorsal column pathway and transient receptor potential vanilloid type 1 in augmentation of cerebral blood flow by upper cervical spinal cord stimulation in rats
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کلمات کلیدی
TRPV1CSCsSCsCBFRTXCVRmotor threshold - آستانه موتورi.t. - آی تی.vasodilation - اتساع عروقCerebral ischemia - ایسکمی مغزیSpinal cord stimulation - تحریک طناب نخاعیcerebral blood flow - جریان خون مغزیresiniferatoxin - رزینیفراتوکسینCerebrovascular resistance - مقاومت مغزی در مغزtransient receptor potential vanilloid type 1 - پتانسیل ترانزیتی وینیلوئید نوع 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Roles of dorsal column pathway and transient receptor potential vanilloid type 1 in augmentation of cerebral blood flow by upper cervical spinal cord stimulation in rats Roles of dorsal column pathway and transient receptor potential vanilloid type 1 in augmentation of cerebral blood flow by upper cervical spinal cord stimulation in rats](/preview/png/6278246.png)
چکیده انگلیسی
Clinical and basic studies have indicated that upper cervical spinal cord stimulation (cSCS) significantly increases cerebral blood flow (CBF), but the mechanisms are incompletely understood. This investigation was conducted to differentiate between stimulation of dorsal column fibers and upper cervical spinal cord cell bodies in cSCS-induced increases in CBF and decreases in cerebrovascular resistance (CVR). cSCS (50 Hz, 0.2 ms, 1 min) was applied on the left C1-C2 dorsal column of pentobarbital anesthetized, ventilated and paralyzed male rats. Laser Doppler flowmetry probes were placed bilaterally over the parietal cortex, and arterial pressure was monitored. cSCS at 30%, 60%, and 90% of motor threshold (MT) produced vasodilation bilaterally in cerebral cortices. Subsequently, cSCS was applied at 90% MT, and ipsilateral responses were recorded. Ibotenic acid (0.3 mg/ml, 0.1 ml) placed on dorsal surface of C1-C2 (n=7) to suppress cell body activity, did not affect cSCS-induced %ÎCBF (42.5±8.1% vs. 36.8±7.1%, P>0.05) and %ÎCVR (â19.4±4.2% vs. â15.2±5.6%, P>0.05). However, bilateral transection of the dorsal column at rostral C1 (n=8) abolished cSCS-induced changes in CBF and CVR. Also, rostral C1 transection (n=7) abolished cSCS-induced changes in CBF and CVR. Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. RTX (2 μg/ml, 0.1 ml) placed on the C1-C2 spinal cord (n=7) did not affect cSCS-induced %ÎCBF (60.2±8.1% vs. 46.3±7.7%, P>0.05) and %ÎCVR (â25.5±3.5% vs. â21.4±8.9%, P>0.05). However, i.v. RTX (2 μg/kg, n=9) decreased cSCS-induced %ÎCBF from 65.0±9.5% to 27.4±7.2% (P<0.05) and %ÎCVR from â28.0±7.6% to â14.8±4.2% (P<0.05). These results indicated that cSCS-increases in CBF and decreases in CVR occurred via rostral spinal dorsal column fibers and did not depend upon C1-C2 cell bodies. Also, our results suggested that cerebral but not spinal TRPV1 was involved in cSCS-induced cerebral vasodilation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 152, Issue 4, 9 April 2008, Pages 950-958
Journal: Neuroscience - Volume 152, Issue 4, 9 April 2008, Pages 950-958
نویسندگان
X. Yang, J.P. Farber, M. Wu, R.D. Foreman, C. Qin,