کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278357 | 1295816 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus
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کلمات کلیدی
POMCtetraethylammonium chlorideα-MSH5-HTLHA8-OH-DPATPBGTTXAgRPNPY5-carboxamidotryptamineGFP5-HT1F receptor5-CT - 5 CT8-hydroxy-2-(di-n-propylamino) tetralin - 8-هیدروکسی 2- (دی-نپروپیلامینو) تترالینK+ channel - K + کانالtetrodotoxin - تترو دوتوکسین Arc - قوسPVN - مالیات بر ارزش افزودهlateral hypothalamic area - منطقه هیپوتالاموس جانبیarcuate nucleus - هسته قوسparaventricular nucleus - هسته پروژسترویکalpha-melanocyte stimulating hormone - هورمون تحریک کننده آلفا ملانوستیHypothalamus - هیپوتالاموسgreen fluorescent protein - پروتئین فلورسنت سبزAgouti-related protein - پروتئین مرتبط با Agoutiproopiomelanocortin - پروپیوملانوکورتینTEA - چایNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus 5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus](/preview/png/6278357.png)
چکیده انگلیسی
A number of anti-obesity agents have been developed that enhance hypothalamic 5-HT transmission. Various studies have demonstrated that arcuate neurons, which express proopiomelanocortin peptides (POMC neurons), and neuropeptide Y with agouti-related protein (NPY/AgRP) neurons, are components of the hypothalamic circuits responsible for energy homeostasis. An additional arcuate neuron population, rat insulin 2 promoter Cre recombinase transgene (RIPCre) neurons, has recently been implicated in hypothalamic melanocortin circuits involved in energy balance. It is currently unclear how 5-HT modifies neuron excitability in these local arcuate neuronal circuits. We show that 5-HT alters the excitability of the majority of mouse arcuate RIPCre neurons, by either hyperpolarization and inhibition or depolarization and excitation. RIPCre neurons sensitive to 5-HT, predominantly exhibit hyperpolarization and pharmacological studies indicate that inhibition of neuronal firing is likely to be through 5-HT1F receptors increasing current through a voltage-dependent potassium conductance. Indeed, 5-HT1F receptor immunoreactivity co-localizes with RIPCre green fluorescent protein expression. A minority population of POMC neurons also respond to 5-HT by hyperpolarization, and this appears to be mediated by the same receptor-channel mechanism. As neither POMC nor RIPCre neuronal populations display a common electrical response to 5-HT, this may indicate that sub-divisions of POMC and RIPCre neurons exist, perhaps serving different outputs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 159, Issue 1, 3 March 2009, Pages 83-93
Journal: Neuroscience - Volume 159, Issue 1, 3 March 2009, Pages 83-93
نویسندگان
K. Hisadome, M.A. Smith, A.I. Choudhury, M. Claret, D.J. Withers, M.L.J. Ashford,