کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278593 | 1295836 | 2007 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses
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کلمات کلیدی
pKaCPPGSQ22536SNXSNX-482mIPSCRRPIEIVGCCsEPSCevoked excitatory postsynaptic currenteEPSCmEPSCCTXmGluRaCSFTTXNMDAN-methyl-d-aspartateω-conotoxin GVIA - ω-کنوتوکسین GVIAadenylyl cyclase - آدنیلات سیکلاز، آدنیلیل سیکلازglutamate release - انتشار گلوتاماتreadily releasable pool - به راحتی استخر آزادtetrodotoxin - تترو دوتوکسین spontaneous excitatory postsynaptic current - جریان Post-synaptic جبری خودبخودیminiature inhibitory postsynaptic current - جریان ممانعت کننده پستانیپتیک مینیاتوریminiature excitatory postsynaptic current - جریان پستیینپتیک مضر تحریک آمیزInter-event Interval - فاصله بین رویدادEntorhinal cortex - قشر انتورینالartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیaction potential - پتانسیل عمل protein kinase A - پروتئین کیناز Avoltage-gated calcium channel - کانال کلسیم با ولتاژMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Neurotransmitter release at CNS synapses occurs via both action potential-dependent and independent mechanisms, and it has generally been accepted that these two forms of release are regulated in parallel. We examined the effects of activation of group III metabotropic glutamate receptors (mGluRs) on stimulus-evoked and spontaneous glutamate release onto entorhinal cortical neurones in rats, and found a differential regulation of action potential-dependent and independent forms of release. Activation of presynaptic mGluRs depressed the amplitude of stimulus-evoked excitatory postsynaptic currents, but concurrently enhanced the frequency of spontaneous excitatory currents. Moreover, these differential effects on glutamate release were mediated by pharmacologically separable mechanisms. Application of the specific activator of adenylyl cyclase, forskolin, mimicked the effect of mGluR activation on spontaneous, but not evoked release, and inhibition of adenylyl cyclase with 9-tetrahydro-2-furanyl)-9H-purin-6-amine (SQ22536) blocked mGluR-mediated enhancement of spontaneous release, but not depression of evoked release. Occlusion studies with calcium channel blockers suggested that the group III mGluRs might depress evoked release through inhibition of both N and P/Q, but not R-type calcium channels. We suggest that the concurrent depression of action potential-evoked, and enhancement of action potential-independent glutamate release operate through discrete second messenger/effector systems at excitatory entorhinal terminals in rat brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 148, Issue 1, 10 August 2007, Pages 7-21
Journal: Neuroscience - Volume 148, Issue 1, 10 August 2007, Pages 7-21
نویسندگان
G.L. Woodhall, G. Ayman, R.S.G. Jones,