کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278736 | 1295856 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic and acute effects of 3,4-methylenedioxy-N-methylamphetamine ('ecstasy') administration on the dynorphinergic system in the rat brain
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
5-HTCREBSDSVTACPPPFCHYPnorepinephrine transporterpDyn3,4-methylenedioxy-N-methylamphetamineMDMADATAmphetamine - آمفتامین هاDopamine transporter - انتقال دهنده دوپامینOpioids - اپیوئیدGene expression - بیان ژنconditioned place preference - ترجیح محل موظف استNET - خالصDopamine - دوپامینdynorphin - دینورفینDynorphin A - دینورفین ASERT - سختsodium dodecyl sulfate - سدیم دودسیل سولفاتSerotonin - سروتونینserotonin transporter - سروتونین حمل کنندهAbuse - سو استفاده کردنprefrontal cortex - قشر prefrontalDyn - مردHPA - میلی بار یا هکتوپاسکالventral tegmental area - ناحیه تگمنتوم شکمیnorepinephrine - نوراپی نفرینNucleus accumbens - هسته accumbensHypothalamus - هیپوتالاموسhypothalamic–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالCaudate putamen - پاتامن Caudateprodynorphin - پروین دینورفین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chronic and acute effects of 3,4-methylenedioxy-N-methylamphetamine ('ecstasy') administration on the dynorphinergic system in the rat brain Chronic and acute effects of 3,4-methylenedioxy-N-methylamphetamine ('ecstasy') administration on the dynorphinergic system in the rat brain](/preview/png/6278736.png)
چکیده انگلیسی
The prodynorphin system is implicated in the neurochemical mechanism of psychostimulants. Exposure to different drugs of abuse can induce neuroadaptations in the brain and affect opioid gene expression. The present study aims to examine the possibility of a common neurobiological substrate in drug addiction processes. We studied the effects of single and repeated 3,4-methylenedioxy-N-methylamphetamine ('Ecstasy') on the gene expression of the opioid precursor prodynorphin, and on the levels of peptide dynorphin A in the rat brain. Acute (8mg/kg, intraperitoneally) 3,4-methylenedioxy-N-methylamphetamine markedly raised, two hours later, prodynorphin mRNA levels in the prefrontal cortex, and in the caudate putamen, whereas it decreased gene expression in the ventral tegmental area. Chronic (8mg/kg, intraperitoneally, twice a day for 7 days) 3,4-methylenedioxy-N-methylamphetamine increased prodynorphin mRNA in the nucleus accumbens, hypothalamus and caudate putamen and decreased it in the ventral tegmental area. Dynorphin A levels increased after chronic treatment in the ventral tegmental area and decreased after acute treatment in the nucleus accumbens, prefrontal cortex and hypothalamus. These findings confirm the role of the dynorphinergic system in mediating the effects of drugs of abuse, such as 3,4-methylenedioxy-N-methylamphetamine, in various regions of the rat brain, which may be important sites for the opioidergic mechanisms activated by addictive drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 137, Issue 1, 2006, Pages 187-196
Journal: Neuroscience - Volume 137, Issue 1, 2006, Pages 187-196
نویسندگان
M. Di Benedetto, C. D'addario, S. Candeletti, P. Romualdi,