کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6278949 1296532 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Histamine selectively potentiates acid-sensing ion channel 1a
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Histamine selectively potentiates acid-sensing ion channel 1a
چکیده انگلیسی
Although acid-sensitive ion channels (ASICs) play an important role in brain functions, the exact mechanism of their physiological activation remain unclear. A possible answer to the intriguing question is that some presently unknown endogenous ligand(s) positively modulate ASICs and enhance their responses to physiologically significant level. In the present work we found that histamine selectively potentiates ASIC1a homomers in CHO cells. Action of histamine was particularly pronounced at modest acidifications, which cause minor response. At these conditions micromolar concentrations of histamine have provided significant potentiation of ASIC1a response. We proposed that histamine and possibly some other endogenous amines can positively modulate ASICs functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 632, 6 October 2016, Pages 136-140
نویسندگان
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