کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6278956 1296532 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic fluoxetine dissociates contextual from auditory fear memory
ترجمه فارسی عنوان
فلوکستین مزمن متضاد از حافظه ترس شنوایی است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Fluoxetine is a medication used to treat Major Depressive Disorder and other psychiatric conditions. These experiments studied the effects of chronic fluoxetine treatment on the contextual versus auditory fear memory of mice. We found that chronic fluoxetine treatment of adult mice impaired their contextual fear memory, but spared auditory fear memory. Hippocampal perineuronal nets, which are involved in contextual fear memory plasticity, were unaltered by fluoxetine treatment. These data point to a selective inability to form contextual fear memory as a result of fluoxetine treatment, and they suggest that a blunting of hippocampal-mediated aversive memory may be a therapeutic action for this medication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 632, 6 October 2016, Pages 152-156
نویسندگان
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