کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279447 1615072 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of cyclin-dependent kinases inhibitor treatment on experimental herpes simplex encephalitis mice
ترجمه فارسی عنوان
اثر درمان مهارکننده های وابسته به سیکلین وابسته به موش های مبتلا به آنسفالیت هرپس سزارین
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Herpes simplex encephalitis(HSE) is the most common and serious viral encephalitis in humans. There is a lack of effective medication to date for HSE. A better understanding of the mediators of tissue damage is essential for finding new targets for therapeutic intervention. In this project, we explored the effect of cyclin-dependent kinases inhibitor olomoucine treatment on experimental HSE mice. The following results were obtained: (1) olomoucine increased survival in HSE mice; (2) olomoucine inhibited microglial activation and reduced HSV-1-induced cytokines release; (3) olomoucine prevented neural cells apoptosis and attenuated brain tissue pathological changes following HSV-1 infection; (4) olomoucine reduced brain edema and improved neurological function in HSE. Overall, olomoucine can induce a blunted inflammatory response, maintain the blood vessel wall intact, improve neurological function and increase survival in HSE mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 627, 3 August 2016, Pages 71-76
نویسندگان
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