کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6279569 | 1615079 | 2016 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intracerebellar vermis histamine facilitates memory consolidation in the elevated T maze model
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کلمات کلیدی
intracerebral microinjectionGADEPMHDCETMelevated T-maze - T-Maze بالاSAL - WILLgeneralized anxiety disorder - اختلال اضطراب فراگیرPanic disorder - اختلال هراسAnxiety - اضطرابelevated plus maze - بالا به همراه پیچ و خمMemory - حافظهSaline - سالینMotor activity - فعالیت موتورCerebellum - مخچهHistamine - هیستامینhistamine dihydrochloride - هیستامین دی هیدروکلرایدLearning - یادگیری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Experimental evidence suggests that the cerebellum plays a more complex role in learning than simply regulating the motor response. Rather, it is thought to play a significant role in the consolidation of emotional memory in mice. Due to the difficulty of interpreting fear and anxiety behaviors-the standard methodology for the study of the histaminergic system and emotional memory-in mice, we propose a behavioral assessment of mice subjected to the Elevated T-maze after histamine microinjection of the cerebellar vermis. Young male Swiss albino mice weighing 25-35 g were used. In addition, locomotor activity was tested in an open field test. Our data suggest that histamine did not affect memory consolidation during escape or open field behavior at the doses used in this study. However, we observed a significant increase in inhibitory avoidance on the second day in animals receiving a dose of 6.8 nmol/0.5 μl, suggesting that histamine facilitates the consolidation of inhibitory avoidance in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 620, 4 May 2016, Pages 33-37
Journal: Neuroscience Letters - Volume 620, 4 May 2016, Pages 33-37
نویسندگان
Bruna Silva-Marques, Anna Carolyna Lepesteur Gianlorenço, Rosana Mattioli,