کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6279625 | 1615079 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic analysis of FGF20 variants in Chinese Han patients with essential tremor
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Essential tremor (ET) is one of the most frequent neurological disorders with elusive etiology, typically characterized by postural and kinetic tremors. Evidence reveals that genetic components are implicated in the development of ET and there are some overlaps between ET and Parkinson's disease in clinical features and etiology. Variants in the fibroblast growth factor 20 gene (FGF20) have been reported to be associated with the risk of Parkinson's disease. To evaluate the association between the FGF20 gene variants and ET susceptibility, we conducted genetic analysis of five FGF20 variants (rs1721100, rs1989754, rs10089600, rs12720208, and rs17550360) in 200 patients with ET and 426 ethnically-matched Chinese Han normal controls. Statistical analysis did not identify significant differences in genotypic or allelic frequencies of variants between ET patients and normal controls (all PÂ >Â 0.05). No related haplotype was found to be related to the risk of ET. The findings indicate the FGF20 gene might not play a dominating role in the genetic predisposition to ET in Chinese Han population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 620, 4 May 2016, Pages 159-162
Journal: Neuroscience Letters - Volume 620, 4 May 2016, Pages 159-162
نویسندگان
Lamei Yuan, Zhi Song, Xiong Deng, Wen Zheng, Zhijian Yang, Yan Yang, Hao Deng,