Research paperMeta-analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer's disease

- We performed meta-analyses to assess the polymorphisms of lipoprotein lipase in AD.
- The Asn291Ser, HindIII and Ser447Ter SNPs were associated with the risk of AD.
- The Asn291Ser, HindIII and Ser447Ter SNPs showed the opposite effects on AD.

AimsWe evaluated the contributions of four polymorphisms of the lipoprotein lipase (LPL) gene to the risk of Alzheimer's disease (AD).MethodsThrough a comprehensive literature search for genetic variants of LPL involved in AD association studies, we found four polymorphisms for the current meta-analyses. These polymorphisms were Asn291Ser(rs268), PvuII(rs285), HindIII(rs320) and Ser447Ter(rs328).ResultsIn total, eight studies with 5064 cases and 5016 controls were retrieved for the meta-analyses of the four genetic variants. The analyses showed that Asn291Ser(rs268) (OR = 2.34, 95% CI = 1.05-5.25, P = 0.04), HindIII(rs320) (OR = 1.44, 95% CI = 1.17-1.78, P = 0.0006), and Ser447Ter(rs328) (OR = 0.80, 95% CI = 0.66-0.98, P = 0.03) were significantly associated with a risk of AD. No association was found between the PvuII(rs285) polymorphism and the risk of AD.ConclusionsOur results showed that Asn291Ser(rs268), HindIII(rs320) and Ser447Ter(rs328) polymorphisms of LPL were associated with a risk of AD. Asn291Ser(rs268) and HindIII(rs320) were predisposing factors of AD, whereas Ser447Ter(rs328) showed a protective effect for AD.