کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6280394 | 1615095 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monosynaptic excitatory transmission from the hippocampal CA1 region to the subiculum
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Monosynaptic excitatory transmission from the hippocampal CA1 region to the subiculum Monosynaptic excitatory transmission from the hippocampal CA1 region to the subiculum](/preview/png/6280394.png)
چکیده انگلیسی
The subiculum is a major output region of the hippocampus, receiving inputs from the CA1 region. We obtained paired patch-clamp recordings from synaptically coupled pairs of CA1 pyramidal cells (CA1PCs) and subicular principal cells (SubPCs), using rat hippocampal organotypic slice cultures. A single action potential in a presynaptic CA1PC evoked a unitary excitatory postsynaptic current in a SubPC (EPSCCA1âSub). The failure rate of the monosynaptic transmission was remarkably low (0.08). Paired-pulse depression in SubPCs was apparent when an interval of presynaptic action potentials was shorter than 50Â ms. When trains of action potentials were induced in a CA1PC, EPSCCA1âSub was significantly depressed with increasing spike frequency (20-100Â Hz). Thus the unitary monosynaptic transmission from a CA1PC to a SubPC is reliable, and depressed in response to frequent inputs, suggesting that the subiculum may function as a low pass filter to provide the downstream brain regions with appropriate information.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 604, 14 September 2015, Pages 42-46
Journal: Neuroscience Letters - Volume 604, 14 September 2015, Pages 42-46
نویسندگان
Xiaoqi Geng, Masahiro Mori,