کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6280779 1615109 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleAssociation between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research articleAssociation between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: A meta-analysis
چکیده انگلیسی


- The association between ANKK1 polymorphisms and ADHD was analyzed using meta-analysis.
- Rs1800497 locus was associated with the risk of ADHD in the dominant model.
- Meta-regression was performed to explore sources of significant heterogeneity.

The role of dopamine neurotransmitter in attention deficit hyperactivity disorder (ADHD) remains controversial. Many molecular studies focusing on dopamine receptors have attempted to analyze the gene polymorphisms involved in dopaminergic transmission. Of these, rs1800497 (TaqIA) single nucleotide polymorphism (SNP) of the dopamine D2 receptor (DRD2) gene has been focused on by the most attention. However, this locus has recently been identified within the exon 8 of ankyrin repeat and kinase domain containing 1 (ANKK1), giving rise to a Glu713-to-Lys substitution in the putative ANKK1 protein. Thus, we performed a meta-analysis to determine whether ANKK1 polymorphism influences the risk of ADHD and examined the relationship between rs1800497 genetic variant and the etiology of ADHD. Relevant case-control studies were retrieved by database searches and selected according to established inclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. Meta-regression, subgroup analysis, sensitivity analysis and cumulative meta-analysis were performed. A total of 11 studies with 1645 cases and 1641 controls were included. In the dominant model, the rs1800497 locus was associated with ADHD, with a pooled OR of 1.785 (95% CI = 1.068-2.984, p = 0.027). Subgroup analysis for ethnicity indicated that the polymorphism was associated with ADHD in Africans (OR = 3.286, 95% CI = 1.434-7.527, p = 0.005), but not in East Asians (OR = 1.513, 95% CI = 0.817-2.805, p = 0.188) and Caucasians (OR = 1.740, 95% CI = 0.928-3.263, p = 0.084). However, the results of meta-regression indicated that publication date (p = 0.601), source of controls (p = 0.685), ethnicity (p = 0.755) and diagnostic criteria (p = 0.104) could not explain the potential sources of heterogeneity. This meta-analysis indicates that the rs1800497 locus may be associated with ADHD. These data provide possible references for future case-control studies in childhood disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 590, 17 March 2015, Pages 101-105
نویسندگان
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