کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6281182 1615114 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationSurgical stress induced depressive and anxiety like behavior are improved by dapsone via modulating NADPH oxidase level
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Short communicationSurgical stress induced depressive and anxiety like behavior are improved by dapsone via modulating NADPH oxidase level
چکیده انگلیسی


- Surgical stress induces depressive and anxiety like behavior in aged mice.
- Elevation of brain oxidative stress was observed in mice following surgical stress.
- Dapsone suppressed surgical stress induced brain oxidative stress.
- Dapsone improved surgical stress induced depressive and anxiety like behavior.
- Effect of dapsone on surgical stress was mediated by inhibiting NADPH oxidase.

Surgical stress induced depression and anxiety like behavior are common complications among aged individuals suffering from surgery. Recent studies proposed that accumulation of oxidative stress is involved in the etiology of stress induced depression and anxiety. Dapsone possesses antioxidant properties, however, whether dapsone is effective in modulating surgical stress induced brain oxidative damage remains uncertain. The present study aimed to investigate the effect of dapsone on surgical stress induced depressive and anxiety like behavior, and brain oxidative stress in a well-established surgical stress model. Depressive and anxiety like behavior accompanied by elevated brain oxidative stress were observed in aged mice underwent abdominal surgery. Pretreatment with 5 mg/kg dapsone significantly improved the behavioral disorder and ameliorated brain oxidative stress in this model. Further investigation, revealed that surgical stress increased brain NADPH oxidase level, while pretreatment with dapsone abrogated the elevation of NADPH oxidase triggered by surgical stress. These findings suggest that dapsone is effective in improving surgical stress induced brain oxidative damage via down-regulating NADPH oxidase level in aged mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 585, 12 January 2015, Pages 103-108
نویسندگان
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