کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281403 | 1615115 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) in the striatum leads to behavioral changes in emotional responses
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کلمات کلیدی
DLSNACEPMDMSHSVAMPARFSTOFTdorsolateral striatum - striatum dorsolateraldorsomedial striatum - striatum dorsomedialOpen field test - آزمایش میدان بازforced swim test - آزمون شناور اجباریStriatum - استریاتومelevated plus maze - بالا به همراه پیچ و خمNucleus accumbens - هسته accumbensEmotion - هیجانherpes simplex virus - ویروس هرپس سیمپلکسEmotional response - پاسخ احساسیAMPA receptor - گیرنده AMPA
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The striatum receives and integrates multiple inputs from diverse areas in the brain and plays a critical role in the regulation of motor activity. However, whether the striatum is involved in the alteration of behavior in the presence of emotional challenges is unknown. Here, we examined whether alterations in the surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) in the dorsal striatum would affect anxiety-related behaviors. We found that the transient expression of G1CT or G2CT, AMPAR-derived peptides, in the dorsomedial striatum led to decreased mobility in high-anxiety circumstances; however, the expression of these peptides in the dorsolateral striatum did not affect anxiety-related behavior. These data suggest that excitatory connections within the dorsomedial striatum play important roles in the control of motor actions in the presence of emotional challenges.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 584, 1 January 2015, Pages 103-108
Journal: Neuroscience Letters - Volume 584, 1 January 2015, Pages 103-108
نویسندگان
Young Lee, Hojin Lee, Hyung-Wook Kim, Bong-June Yoon,