کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281670 | 1615117 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract
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کلمات کلیدی
ROINSTTTXDNQXmEPSCpresynapticSCOSANTArtemisia scopariaElectrophysiology - الکتروفیزیولوژیtetrodotoxin - تترو دوتوکسین Calcium imaging - تصویر برداری کلسیمیminiature excitatory postsynaptic current - جریان پستیینپتیک مضر تحریک آمیزregion of interest - منطقه مورد نظرnucleus of the solitary tract - هسته دستگاه انفرادیbotanical - گیاه شناسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract](/preview/png/6281670.png)
چکیده انگلیسی
Artemisia extracts have been used as remedies for a variety of maladies related to metabolic and gastrointestinal control. Because the vagal afferent-nucleus of the solitary tract (NST) synapse regulates the same homeostatic functions affected by Artemisia, it is possible that these extracts may have activity at the synaptic level in the NST. Therefore, we evaluated how extracts of three common medicinal Artemisia species, Artemisia santolinifolia (SANT), Artemisia scoparia (SCO), and Artemisia dracunculus L (PMI-5011), modulate the excitability of the glutamatergic vagal afferent-NST synapse. Our in vitro live cell calcium imaging data from prelabeled vagal afferent terminals show that SANT extract is a positive modulator of vagal afferent calcium levels, as the extract significantly increased the calcium signal relative to the time control. Neither SCO nor PMI-5011 extract altered the vagal calcium signals compared to the time control. Furthermore, whole cell voltage-clamp recordings from NST neurons corroborated the vagal terminal calcium data in that SANT extract also significantly increased miniature excitatory postsynaptic current (mEPSC) frequency in NST neurons. These data suggest that SANT extract could be a pharmacologically significant mediator of glutamatergic neurotransmission within the CNS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 582, 17 October 2014, Pages 115-119
Journal: Neuroscience Letters - Volume 582, 17 October 2014, Pages 115-119
نویسندگان
Katie M. Vance, David M. Ribnicky, Richard C. Rogers, Gerlinda E. Hermann,