کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6281741 1615120 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice
ترجمه فارسی عنوان
محرومیت حاد کلیه باعث افزایش هیپرلوکوموتیک ناشی از کوکائین در موش می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Sleep deprivation is common place in modern society. Nowadays, people tend to self-impose less sleep in order to achieve professional or social goals. In the social context, late-night parties are frequently associated with higher availability of recreational drugs with abuse potential. Physiologically, all of these drugs induce an increase in dopamine release in the mesolimbic dopaminergic system, which leads to hyperlocomotion in rodents. Sleep deprivation also seems to play an important role in the events related to the neurotransmission of the dopaminergic system by potentiating its behavioral effects. In this scenario, the aim of the present study was to investigate the effects of total sleep deprivation (6 h) on the acute cocaine-induced locomotor stimulation in male mice. Animals were sleep deprived or maintained in their home cages and subsequently treated with an acute i.p. injection of 15 mg/kg cocaine or saline and observed in the open field. Total sleep deprivation for 6 h potentiated the hyperlocomotion induced by acute cocaine administration. In addition, the cocaine sleep deprived group showed a decreased ratio central/total locomotion compared to the cocaine control group, which might be related to an increase in the impulsiveness of mice. Our data indicate that acute periods of sleep loss should be considered risk factors for cocaine abuse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 579, 5 September 2014, Pages 130-133
نویسندگان
, , , , , , , , , , , , ,