کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6281998 1615130 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Satellite glial cells in dorsal root ganglia are activated in experimental autoimmune encephalomyelitis
ترجمه فارسی عنوان
سلول های گلیال سلولی در گانگلیا ریشه پشتی در آنسفالومیلیت های اتوایمیون تجربی فعال می شوند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Pain is a serious and common problem with patients suffering from multiple sclerosis (MS). Very little has been done to investigate the peripheral mechanisms of pain in MS. Here we used a mouse model of experimental autoimmune encephalomyelitis (EAE) to investigate the possible contribution of satellite glial cells (SGCs) to pain in MS. EAE mice had reduced pain thresholds 10 days after disease induction. We examined dorsal root ganglia and found increased expression of glial fibrillary acidic protein in SGCs, a marker of SGC activation, and increased coupling among SGCs, a known component of activated SGCs. Activated SGCs have previously been shown to contribute to pain in other classical neuropathic pain models, suggesting that pain in multiple sclerosis has a peripheral component.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 569, 21 May 2014, Pages 59-62
نویسندگان
, , , ,