Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice

► Pharmacological inhibition of the mTOR pathway alters the hippocampal progenitor pool. ► Pharmacological inhibition of mTOR pathway impairs hippocampal development. ► Inhibition of mTOR pathway causes increased proliferation accompanied by increased apoptosis. ► This leads to decreased functional neurons that are important of cognition and memory.