Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; COX2; Cytochrome c oxidase subunit II; GAP 43; growth-associated protein 43; GFAP; glial fibrillary acidic protein; GLUT; glucose transporter; Iba 1; Ionized calcium binding adaptor molecule 1; KHK; ketohexokinase; MBP; Myelin Protein Basic; MetS; metabol
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Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; TBI; traumatic brain injury; DCX; doublecortin; Iba-1; ionized calcium binding adaptor molecule 1; TLR4; toll like receptor 4; IL-1β; interleukin 1 beta; Traumatic brain injury; Alcohol; Axon degeneration; Microglia; Neuroinflammation; Learning and memor
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; ACA; asphyxial cardiac arrest; CL; cardiolipin; complex IÂ +Â III; NADH:cytochrome c oxidoreductase; complex IIÂ +Â III; succinate:cytochrome c oxidoreductase; ECG; electrocardiogram; GFAP; glial fibrillary acidic protein; IBA1; ionized calcium binding ad
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AD; Alzheimer's disease; Cd; cluster of differentiation; CNS; central nervous system; COX; cyclooxygenase (prostaglandin-endoperoxide synthase, EC 1.14.99.1); DIV; days in vitro; DMEM; Dulbecco's Modified Eagle's Medium; E18; embryonic day 18; ELISA
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Polyphenols; Antibiotics; Antioxidants; PACAP; Aβ; β-amyloid; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; BBB; blood-brain barrier; BDNF; brain-derived neurotrophic factor; CAT; catalase; CNS; central nervous system; COX-2; cyclooxyge
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; ANOVA; analysis of variance; BBB; blood-brain barrier; CCA; common carotid artery; Iba1; ionized calcium binding adaptor molecule 1; IFNγ; interferon gamma; IL-1β; interleukin-1β; IL-6; interleukin-6; IL-10; interleukin-10; IL-12; interleukin-12; IL-23
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; BLA; Basolateral Amygdala; CA1; Cornu Ammonis 1; CA3; Cornu Ammonis 3; DGib; Dentate Gyrus inner blade; PFC; the medial Prefrontal Cortex Zilles cg1 region; DMS; dorso-medial striatum; IBA-1; ionized calcium binding adaptor molecule 1; MWM; Morris water m
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AP; Anterior-posterior; DAPI; 4â²,6 diamidino-2-phenylindole; DV; Dorsal-ventral; ET-1; Endothelin-1; GFAP; Glial fibrillary acidic protein; GST-pi; Glutathione S-transferase Pi; Iba1; Ionized calcium binding adaptor molecule 1; PBS; Phosphate buffer
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; MCs; mast cells; MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; WT; wildtype; SCI; spinal cord injury; mMCP4; mouse mast cell protease 4; BMS; basso mouse scale; GFAP; glial fibrillary acidic protein; MBP; myelin basic protein; Ib
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; aCSF; artificial cerebrospinal fluid; ALDH1L1; aldehyde dehydrogenase 1 family member L1; CR; cochlear removal; DAPI; 4â²,6-diamidino-2-phenylindole; DCN; dorsal cochlear nucleus; GFAP; glial fibrillary acidic protein; HEPES; 4-(2-hydroxyethyl)-1-piperaz
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; CC; corpus callosum; Cdm; caudate nucleus (medial part); CG; cingulate cortex; Cla; claustrum; DAPI; 4â²,6-diamidin-2-phenylindole; DIV; days in culture (in vitro); DMEM; Dulbecco's modified Eagle's medium; EGP; external globus pallidus; Ent; entorhinal
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AUC; area under the curve; BLA; basolateral amygdala; BSA; bovine serum albumin; CA1; cornu ammonis region 1; CA 3; cornu ammonis region 3; CFC; contextual fear conditioning test; DCX; doublecortin-X; DG; dentate gyrus; DGib; dentate gyrus inner blade; ED
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; ANOVA; analysis of variance; ChAT; choline acetyltransferase; CNS; central nervous system; Iba1; ionized calcium binding adaptor molecule 1; LLS; levator labii superioris muscle; N; number; Nv; numerical density; SD; standard deviation; TNR; tenascin-R; V
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Angiotensin; Renin; Inflammation; Sympathetic nervous system; Microglia; Blood pressure; ACE; angiotensin-converting enzyme; ACE2; angiotensin-converting enzyme 2; AGT; angiotensinogen; Ang-II; angiotensin-II; Ang-(1-7); angiotensin (1-7); AT1R; angio
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; CLP; cecal ligation and puncture; EA; electroacupuncture; -MWM; Morris water maze; MDA; malondialdehyde; SOD; superoxide dismutase; CAT; catalase; TLR-4; toll-like receptor-4; NFκB; nuclear factor-kappa B; Iba 1; ionized calcium binding adaptor molecul
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; ER; endoplasmic reticulum; AMD; age-related macular degeneration; RPE; retinal pigment epithelium; PUFAs; polyunsaturated fatty acids; ROS; reactive oxygen species; NRF-2; nuclear factor-erythroid 2-related factor-2; ARE; antioxidant response element; Kea
Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Aβ; β-amyloid; CNS; central nervous system; CR3; complement receptor 3; DAMPs; damage associated molecular patterns; DEPs; diesel exhaust particles; DHE; dihydroethidium; Erk; extracellular regulated protein kinases; HMGB1; high-mobility group box 1; Ib
Multiple mechanisms underlying neuroprotection by secretory phospholipase A2 preconditioning in a surgically induced brain injury rat model
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; SBI; surgical brain injury; PLA2; phospholipase A2; PPC; PLA2 preconditioning; 5-LOX; 5-lipoxygenase; AA; arachidonic acid; LTB4; leukotriene-B4; BWC; brain water content; WBC; white blood cells; GFAP; glial fibrillary acidic protein; MPO; myeloperoxidase
New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; 2-MCA; 2-methylcitrate; AKG; α-ketoglutarate; BBB; blood-brain barrier; CSF; cerebrospinal fluid; CNS; central nervous system; cTIN; chronic tubulointerstitial nephritis; DIV; day in vitro; FGF; fibroblast growth factor; GalC; galactocerebroside; GDH; gl
Genetic Modulation of HSPA1A Accelerates Kindling Progression and Exerts Pro-convulsant Effects
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; CA1 and CA3; cornu ammonis region 1 and 3; EEG; electroencephalography; HMGB1; high-mobility group box 1; hsp70; heat shock protein 70; Iba1; ionized calcium binding adaptor molecule 1; iNOS; nitric oxide synthase; PTZ; pentylenetetrazol; TG; transgenic;
Hv1 proton channel facilitates production of ROS and pro-inflammatory cytokines in microglia and enhances oligodendrocyte progenitor cells damage from oxygen-glucose deprivation in vitro
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Voltage-gated proton channel Hv1; Reactive oxygen species (ROS); Pro-inflammatory cytokines; Microglia; Oligodendrocyte; Oxygen-glucose deprivation (OGD); CNS; central nervous system; DCFH-DA; dichlorodihydrofluorescein diacetate; DMEM; Dulbecco's modifie
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; α-synuclein; G2019S knock-in mice; iba-1; LRRK2; Microglia; Parkinson's disease; AAV2/9; adeno-associated viral vector pseudotype 2/9; DA; dopamine; G2019S knock-in; G2019S KI; hα-syn; p.A53T human α-synuclein; ionized calcium binding adaptor molecule
The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; BBB; blood brain barrier; BBBD; blood brain barrier disruption; EAAC1; excitatory amino acid carrier type 1; GFAP; glial fibrillary acidic protein; GSH; reduced glutathione; GSSG; oxidized glutathione; HPLC-ECD; high performance liquid chromatography with
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Major depression; Nicotinic receptor; Microglia; α7 positive allosteric modulator; Neuroinflammation; Mice; MDD; major depressive disorder; CNS; central nervous system; LPS; lipopolysaccharide; nAChR; nicotinic acetylcholine receptor; PAM; positive allos
Minocycline protects developing brain against ethanol-induced damage
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Apoptosis; Development; Fetal alcohol syndrome; Inflammation; Microglia; Neurodegeneration; AD; Alzheimer's disease; CNS; central nervous system; FASD; fetal alcohol spectrum disorder; GSK3β; Glycogen synthase kinase 3 beta; Iba-1; ionized calcium bindin
Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Apoptosis; Cell proliferation; Depression; Emotional behavior; Olfactory bulbectomy; Neuroinflammation; ANOVA; analysis of variance; Bax; Bcl-2-associated protein X; Bcl-2; B cell lymphoma/leukemia gene 2; BDNF; brain-derived neurotrophic factor; BrdU; 5-
BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Brain-derived neurotrophic factor; Incisional pain; Long-term potentiation; Neonatal rat; Spinal dorsal horn; ACC; the anterior cingulate cortex; AMPAR; α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptor; ANOVA; analysis of variance; BDNF;
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Microglial priming; Aging; Parkinson's disease; MMP-8 inhibitor; Systemic inflammation; Neuroinflammation; CSF; macrophage colony-stimulating factor; EMSA; electrophoretic mobility shift assay; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium
NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; BDNF; brain derived neurotrophic factor; GDNF; glia derived neurotrophic factor; GFAP; glial fibrillary protein; Iba-1; ionized calcium binding adaptor molecule 1; IL-1β; interleukin-1β; LPS; lipopolysaccharide; LME; l-leucine-methyl esther; MAPK; mitog
The role of system Xcâ in methamphetamine-induced dopaminergic neurotoxicity in mice
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Methamphetamine neurotoxicity; System Xcâ; xCT knockout mice; Glutamate-related toxicity; Oxidative damage; Striatum; ANOVA; analysis of variance; CNS; central nervous system; DA; dopamine; DCF; dichlorofluorescin; DCFH-DA; 2â²,7â²-dichlorofluorescin
Alteration of nuclear factor-kappaB pathway promote neuroinflammation depending on the functions of estrogen receptors in substantia nigra after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; PD; Parkinson's disease; SN; substantia nigra; Iba1; ionized calcium binding adaptor molecule 1; MPP+; 1-methyl-4-phenylpyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; TNF-α; tumor necrosis factor-alpha; b.w.; body weight; GFAP; glial fib
Stimulation of spinal dorsal horn β2-adrenergic receptor ameliorates neuropathic mechanical hypersensitivity through a reduction of phosphorylation of microglial p38 MAP kinase and astrocytic c-jun N-terminal kinase
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; β-adrenergic receptors; Neuropathic pain; Mechanical allodynia; Spinal dorsal horn; Glial cells; MAP kinases; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium binding adaptor molecule 1; JNK; c-jun N-terminal kinase; MAPKs; mitogen-activated
Hypertension impairs hippocampus-related adult neurogenesis, CA1 neuron dendritic arborization and long-term memory
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; 2K1C; 2 kidneys, 1 clip method; BDNF; brain-derived neurotrophic factor; BrdU; 5-bromo-2-deoxyuridine; DCX; doublecortin; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium binding adaptor molecule 1; POD; post-operation day; SH; spontaneously h
The effect of B-cell depletion in the Theiler's model of multiple sclerosis
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; BCD; B cell depletion; MS; multiple sclerosis; TMEV; Theiler's murine encephalomyelitis virus; TMEV-IDD; Theiler's murine encephalomyelitis virus-induced demyelinating disease; CD; cluster of differentiation; RT-PCR; reverse transcription polymerase chain
Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; ALSP; adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; CSF-1R; colony stimulating factor-1 receptor; FA; fractional anisotropy; GFAP; glial fibrillary acidic protein; G-CSF; granulocyte-CSF; GM-CSF; granulocyte macrophage-CSF; HDL
A single dose of PPARγ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; CCI; controlled cortical impact; CNS; central nervous system; COX-2; cyclooxygenase-2; GFAP; glial fibrillary acidic protein; GSH-Px; glutathione peroxidase; Iba1; ionized calcium binding adaptor molecule 1; IL-1α; interleukin 1-alpha; IL-6; interleukin-
Involvement of p38 MAPK activation mediated through AT1 receptors on spinal astrocytes and neurons in angiotensin II- and III-induced nociceptive behavior in mice
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Angiotensin II; Angiotensin III; AT1 receptors; Nociceptive behavior; p38 MAPK; Astrocyte; Neuron; Intrathecal administration; Mice; Ang; angiotensin; AT1; Ang II type 1; AT2; Ang II type 2; i.t.; intrathecal; MAPK; mitogen-activated protein kinase; ACE;
Astrogliosis as a therapeutic target for neurodegenerative diseases
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BB14®; nerve growth factor-like peptide; BDNF; brain-derived neurotrophic factor; Ca2+; calcium; CNS; central nervous system; COX-1/2; cyclooxygenase-1/2; EAAC1; ex
Dynamic, in vivo, real-time detection of retinal oxidative status in a model of elevated intraocular pressure using a novel, reversibly responsive, profluorescent nitroxide probe
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Oxidative stress; Retina; Fluorescent probe; Nitroxide; Reactive oxygen species; Ischemia; Reperfusion; DMSO; Dimethyl sulfoxide; ERG; Electroretinogram; GFAP; Glial fibrillary acidic protein; IBA-1; Ionized calcium binding adaptor molecule 1; IOP; Intrao
Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AD; Alzheimer's disease; Aβ; amyloid beta; APP; amyloid precursor protein; APP/PS1; APPswe/PS1dE9; IL-1β; interleukin-1 beta; CCR2; chemokine (C-C motif) receptor 2; BMD; bone marrow-derived; eGFP; enhanced green fluorescent protein; Iba1; ionized calci
Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; CNS; central nervous system; DIV; days in vitro; DMEM; Dulbecco's Modified Eagle's Medium; DRG; dorsal root ganglion; E; embryonic day; FABP; fatty-acid-binding protein; FBS; fetal bovine serum; FGF; fibroblast growth factor; GFAP; glial fibrillary acidic
Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; BrdU; 5-bromo-2-deoxyuridine; DCX; doublecortin; DG; dentate gyrus; GFP; green fluorescent protein; GS; glutamine synthetase; Iba1; ionized calcium binding adaptor molecule 1; mTOR; mammalian target of rapamycin; Neu N; neuronal nuclei; Dentate gyrus; Neu
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; PD; Parkinson's disease; MPTP; 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine; SNpc; substantia nigra pars compacta; TH; tyrosine hydroxylase; Iba-1; ionized calcium binding adaptor molecule 1; GM130; cis-Golgi matrix protein 130; DAPI; 4â²,6-diamidino-2-p
Research ReportAnti-inflammatory effects of OBA-09, a salicylic acid/pyruvate ester, in the postischemic brain
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; OBA-09; oxopropanoyloxy benzoic acid; COX-2; cyclooxygenase-2; iNOS; inducible no synthase; Iba-1; ionized calcium binding adaptor molecule 1; IL-1Î; interleukin-1beta; Mac-2; macrophage galactose-specific lectin-2; MCAO; middle cerebral artery occlusion
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; TDP-43; Tar DNA binding protein; Aβ; β-amyloid; FTLD; fronto-temporal lobar dementia; ALS; amyotrophic lateral sclerosis; Lv; lentivirus; GFAP; glial neurofibrillary proteins; IBA-1; ionized calcium binding adaptor molecule 1; TNF-α; tumor necrosis fac
Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AD; Alzheimer's disease; AIDS; Acquired Immune Deficiency Syndrome; ALS; amyotrophic lateral sclerosis; APAF-1; apoptotic protease activating factor 1; BUGT; human bilirubin-uridine 5â²-diphosphate-glucuronosyl-transferase; CNS; central nervous system;
Full Length ArticlesDeficits in axonal transport in hippocampal-based circuitry and the visual pathway in APP knock-out animals witnessed by manganese enhanced MRI
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; AD; Alzheimer's disease; APP; Amyloid precursor protein; APLP1; Amyloid precursor-like protein 1; APLP2; Amyloid precursor-like protein 2; Aβ; amyloid-β; ChAT; choline acetyltransferase; Iba1; Ionized calcium binding adaptor molecule 1; NGF; nerve growt
Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; ATP; adenosine tri-phosphate; BPI-sf; brief pain inventory short form; CNS; central nervous system; GFAP; glial fibrillary acidic protein; GM-CSF; granulocyte macrophage colony stimulating factor; Iba-1; ionized calcium binding adaptor molecule 1; IC50; i
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; FPI; fluid percussion injury; GAP43; growth-associated protein 43; Iba-1; ionized calcium binding adaptor molecule 1; MHC; major histocompatibility complex; qRT-PCR; quantitative real-time PCR; S1BF; somatosensory barrel field; TBI; traumatic brain injury
Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease
Keywords: مولکول آداپتور اتصال دهنده کلسیم یونیزه 1; Preclinical Alzheimer's disease; Aβ-oligomers; Inflammation; iNOS; COX-2; AD; Alzheimer's disease; MCI; mild cognitive impairment; Aβ; amyloid-β peptide; Tg; transgenic; APP; amyloid precursor protein; ADDLs; Alzheimer's disease diffusible ligands; M