کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10802224 | 1055669 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination
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کلمات کلیدی
PBSMACSPDGFUCBOPCFABPFGFMBPGFAPFBSITSDMEMDRGdorsal root ganglion - گانگلیون ریشه پشتیIba-1 - IBA-1Dulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoROS - ROSunconjugated bilirubin - بیلی روبین غیر مرتبطCNS - دستگاه عصبی مرکزیDIV - دیوdays in vitro - روز in vitroembryonic day - روز جنینیpostnatal day - روز پس از زایمانfetal bovine serum - سرم جنین گاوOligodendrocyte precursor cells - سلولهای پیش ماده Oligodendrocytecentral nervous system - سیستم عصبی مرکزیperipheral nervous system - سیستم عصبی پیرامونیplatelet-derived growth factor - فاکتور رشد حاصل از پلاکتfibroblast growth factor - فاکتور رشد فیبروبلاستPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریmagnetic-activated cell sorting - مرتب سازی سلول های فعال مغناطیسیionized calcium binding adaptor molecule 1 - مولکول آداپتور اتصال دهنده کلسیم یونیزه 1Myelination - میلیناسیونGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالFatty-acid-binding protein - پروتئین متصل به اسید چربMyelin basic protein - پروتئین پایه میلینPNS - کارمندان دولتReactive oxygen species - گونههای فعال اکسیژنplatelet-derived growth factor receptor α - گیرنده عامل فاکتور رشد فاکتور αoligodendrocytes - یاخته کم شاخه، الیگودندروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oligodendrocytes are neuroglial cells responsible, within the central nervous system, for myelin sheath formation that provides an electric insulation of axons and accelerate the transmission of electrical signals. In order to be able to produce myelin, oligodendrocytes progress through a series of differentiation steps from oligodendrocyte precursor cells to mature oligodendrocytes (migration, increase in morphologic complexity and expression pattern of specific markers), which are modulated by cross talk with other nerve cells. If during the developmental stage any of these mechanisms is affected by toxic or external stimuli it may result into impaired myelination leading to neurological deficits. Such being the case, several approaches have been developed to evaluate how oligodendrocyte development and myelination may be impaired. The present review aims to summarize changes that oligodendrocytes suffer from precursor cells to mature ones, and to describe and discuss the different in vitro models used to evaluate not only oligodendrocyte development (proliferation, migration, differentiation and ability to myelinate), but also their interaction with neurons and other glial cells. First we discuss the temporal oligodendrocyte lineage progression, highlighting the differences between human and rodent, usually used as tissue supply for in vitro cultures. Second we describe how to perform and characterize the different in vitro cultures, as well as the methodologies to evaluate oligodendrocyte functionality in each culture system, discussing their advantages and disadvantages. Finally, we briefly discuss the current status of in vivo models for oligodendrocyte development and myelination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 9, September 2014, Pages 1917-1929
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1843, Issue 9, September 2014, Pages 1917-1929
نویسندگان
Andreia Barateiro, Adelaide Fernandes,